{"updated":"2026-11-07","scope":"常见结构类与有文献依据的酶条目；非所有菌株的穷尽目录","bonds":{"G":["GlcNAc -> MurNAc","GlcNAc-beta(1-4)-MurNAc","glucosaminidase"],"M":["MurNAc -> GlcNAc","MurNAc-beta(1-4)-GlcNAc","muramidase / LT"],"A":["MurNAc -> L-Ala1","MurNAc lactyl-CO-NH-L-Ala1","NAM-L-Ala amidase"],"12":["L-Ala1 -> D-Glu2","L-Ala1-D-Glu2","L-Ala–D-Glu endopeptidase (L,D-endopeptidase)"],"23":["D-Glu2/iGln2 -> X3","gamma-D-Glu/D-isoGln2-X3","D,L-endopeptidase / terminal D,L-CP"],"34":["X3 -> D-Ala4","X3-D-Ala4","L,D-carboxypeptidase"],"45":["D-Ala4 -> D-Ala5","D-Ala4-D-Ala5","D,D-carboxypeptidase"],"43":["D-Ala4 -> acceptor","D-Ala4-(bridge N terminus or X3 amino group)","crosslink endopeptidase"],"33":["X3 -> acceptor","X3-(bridge N terminus or X3 amino group)","3-3 crosslink endopeptidase"],"BR":["within bridge","bridge-internal peptide bond; positional preference is enzyme-specific","bridge endopeptidase"],"U":["未定 / unresolved","No bond-level assignment in this atlas","not placed on a precise bond"]},"enzymes":[{"id":"E001","species":"S. aureus","name":"Atl-GL","sites":["G"],"activity":"N-acetylglucosaminidase","refs":["R03","R04"],"note":"Atl 的糖苷酶部分","status":"A","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"The glucosaminidase portion of Atl.","es":"Porción glucosaminidasa de Atl."},"roles":["hydrolase"],"aliases":[],"entryType":"domain","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; 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activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E062","species":"M. tuberculosis","name":"RipB","sites":["23"],"activity":"D,L-endopeptidase","refs":["R45"],"note":"","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"","es":""},"roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E063","species":"M. tuberculosis","name":"Ami1","sites":["A"],"activity":"NAM-L-Ala amidase","refs":["R45"],"note":"","status":"A","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"","es":""},"roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E064","species":"M. tuberculosis","name":"RpfA","sites":["U"],"activity":"glycan-active resuscitation factors","refs":["R45","R110"],"note":"不同成员/菌种的胞壁质酶与LT分类需分别核对","status":"P","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Muramidase versus LT activity must be checked for each member and species.","es":"La actividad muramidasa o LT debe verificarse por miembro y especie."},"roles":["hydrolase","candidate"],"aliases":["rpfA"],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E065","species":"E. coli","name":"AmiA","sites":["A"],"activity":"NAM-L-Ala amidase","refs":["R69"],"note":"周质细胞分离酶","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Periplasmic cell-separation enzyme.","es":"Enzima periplásmica de separación celular."},"roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E066","species":"E. coli","name":"AmiB","sites":["A"],"activity":"NAM-L-Ala amidase","refs":["R69"],"note":"周质细胞分离酶","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Periplasmic cell-separation enzyme.","es":"Enzima periplásmica de separación celular."},"roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E067","species":"E. coli","name":"AmiC","sites":["A"],"activity":"NAM-L-Ala amidase","refs":["R69"],"note":"周质细胞分离酶","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Periplasmic cell-separation enzyme.","es":"Enzima periplásmica de separación celular."},"roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E068","species":"E. coli","name":"AmiD","sites":["A"],"activity":"NAM-L-Ala amidase","refs":["R69"],"note":"","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"","es":""},"roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E069","species":"E. coli","name":"MepS / Spr","sites":["43","33","34"],"activity":"crosslink endopeptidase + L,D-carboxypeptidase","refs":["R46","R47"],"note":"2021产物分析支持双交联切割及四肽修剪；各底物相对活性不同","status":"A","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"2021 product analysis supports both crosslink classes and tetrapeptide trimming; relative activities differ.","es":"El análisis de 2021 apoya ambos tipos de entrecruzamiento y recorte de tetrapéptidos; las actividades relativas difieren."},"roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E070","species":"E. coli","name":"MepH / YdhO","sites":["43","33","34"],"activity":"crosslink endopeptidase + L,D-carboxypeptidase","refs":["R46","R47"],"note":"2021产物分析支持双交联切割及四肽修剪；各底物相对活性不同","status":"A","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"2021 product analysis supports both crosslink classes and tetrapeptide trimming; relative activities differ.","es":"El análisis de 2021 apoya ambos tipos de entrecruzamiento y recorte de tetrapéptidos; las actividades relativas difieren."},"roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E071","species":"E. coli","name":"MepM / YebA","sites":["43","33"],"activity":"4-3 / 3-3 crosslink endopeptidase","refs":["R46","R47"],"note":"2021研究补充3-3交联切割证据","status":"A","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"A 2021 study added evidence of 3–3 crosslink cleavage.","es":"Un estudio de 2021 añadió evidencia de corte de enlaces 3–3."},"roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E072","species":"E. coli","name":"MepA","sites":["43","33"],"activity":"4-3 / 3-3 crosslink endopeptidase","refs":["R47"],"note":"所引原始研究引用更早的生化表征","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"The cited primary study refers to earlier biochemical characterization.","es":"El estudio primario citado remite a una caracterización bioquímica anterior."},"roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E073","species":"E. coli","name":"MepK","sites":["33","43"],"activity":"crosslink endopeptidase","refs":["R47"],"note":"偏好3-3；较弱4-3活性也有报道","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Prefers 3–3 crosslinks; weaker activity on 4–3 bonds is also reported.","es":"Prefiere enlaces 3–3; también se describe actividad menor sobre 4–3."},"roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E074","species":"E. coli","name":"PBP4 / DacB","sites":["43","45"],"activity":"D,D-carboxypeptidase / endopeptidase","refs":["R69","R83"],"note":"个别PBP另有CP活性，见文献底物条件","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Some PBPs also have carboxypeptidase activity; consult the substrate conditions in the source.","es":"Algunas PBP también tienen actividad carboxipeptidasa; consultar el sustrato en la fuente."},"roles":["hydrolase"],"aliases":[],"entryType":"protein","pbpClass":"C","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E075","species":"E. coli","name":"PBP7 / PbpG","sites":["43"],"activity":"D,D-endopeptidase","refs":["R69"],"note":"个别PBP另有CP活性，见文献底物条件","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Some PBPs also have carboxypeptidase activity; consult the substrate conditions in the source.","es":"Algunas PBP también tienen actividad carboxipeptidasa; consultar el sustrato en la fuente."},"roles":["hydrolase"],"aliases":[],"entryType":"protein","pbpClass":"C","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E076","species":"E. coli","name":"PBP5 / DacA","sites":["45"],"activity":"D,D-carboxypeptidase","refs":["R69"],"note":"","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"","es":""},"roles":["hydrolase"],"aliases":[],"entryType":"protein","pbpClass":"C","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E077","species":"E. coli","name":"PBP6a / DacC","sites":["45"],"activity":"D,D-carboxypeptidase","refs":["R69"],"note":"","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"","es":""},"roles":["hydrolase"],"aliases":["PBP6 / DacC","PBP6"],"entryType":"protein","pbpClass":"C","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E078","species":"E. coli","name":"Slt70","sites":["M"],"activity":"lytic transglycosylase","refs":["R69"],"note":"内切/外切、聚合度与交联偏好不同；此图只标共同断键位置","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Endo/exo action and chain-length or crosslink preferences vary; the map shows only the shared bond position.","es":"Varían la acción endo/exo y las preferencias por longitud o entrecruzamiento; el mapa muestra el enlace compartido."},"roles":["lyticTG"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E079","species":"E. coli","name":"MltA","sites":["M"],"activity":"lytic transglycosylase","refs":["R69","R121"],"note":"内切/外切、聚合度与交联偏好不同；此图只标共同断键位置。2026 年 5 月预印本报告其参与隔膜周转；不是新催化特异性的同行评审证明。","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Endo/exo action and chain-length or crosslink preferences vary; the map shows only the shared bond position. A May 2026 preprint reports septal turnover involvement; this is not peer-reviewed proof of a new catalytic specificity.","es":"Varían la acción endo/exo y las preferencias por longitud o entrecruzamiento; el mapa muestra el enlace compartido. Un preprint de mayo de 2026 informa participación en recambio septal; no es evidencia revisada de una especificidad catalítica nueva."},"roles":["lyticTG"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E080","species":"E. coli","name":"MltB","sites":["M"],"activity":"lytic transglycosylase","refs":["R69"],"note":"内切/外切、聚合度与交联偏好不同；此图只标共同断键位置","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Endo/exo action and chain-length or crosslink preferences vary; the map shows only the shared bond position.","es":"Varían la acción endo/exo y las preferencias por longitud o entrecruzamiento; el mapa muestra el enlace compartido."},"roles":["lyticTG"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E081","species":"E. coli","name":"MltC","sites":["M"],"activity":"lytic transglycosylase","refs":["R69"],"note":"内切/外切、聚合度与交联偏好不同；此图只标共同断键位置","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Endo/exo action and chain-length or crosslink preferences vary; the map shows only the shared bond position.","es":"Varían la acción endo/exo y las preferencias por longitud o entrecruzamiento; el mapa muestra el enlace compartido."},"roles":["lyticTG"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E082","species":"E. coli","name":"MltD","sites":["M"],"activity":"lytic transglycosylase","refs":["R69"],"note":"内切/外切、聚合度与交联偏好不同；此图只标共同断键位置","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Endo/exo action and chain-length or crosslink preferences vary; the map shows only the shared bond position.","es":"Varían la acción endo/exo y las preferencias por longitud o entrecruzamiento; el mapa muestra el enlace compartido."},"roles":["lyticTG"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E083","species":"E. coli","name":"MltE","sites":["M"],"activity":"lytic transglycosylase","refs":["R69"],"note":"内切/外切、聚合度与交联偏好不同；此图只标共同断键位置","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Endo/exo action and chain-length or crosslink preferences vary; the map shows only the shared bond position.","es":"Varían la acción endo/exo y las preferencias por longitud o entrecruzamiento; el mapa muestra el enlace compartido."},"roles":["lyticTG"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E084","species":"E. coli","name":"MltF","sites":["M"],"activity":"lytic transglycosylase","refs":["R69"],"note":"内切/外切、聚合度与交联偏好不同；此图只标共同断键位置","status":"B","origin":"endogenous","substrate":"PG / muropeptide","note_i18n":{"en":"Endo/exo action and chain-length or crosslink preferences vary; the map shows only the shared bond position.","es":"Varían la acción endo/exo y las preferencias por longitud o entrecruzamiento; el mapa muestra el enlace compartido."},"roles":["lyticTG"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；活性以条目文献为准","en":"Listed species; activity is bounded by the cited evidence","es":"Especie indicada; actividad limitada a la evidencia citada"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E085","species":"E. coli","name":"MltG","sites":["M"],"activity":"lytic transglycosylase","refs":["R76"],"note":"偏好新生PG；不同菌的同源蛋白未必同属LT","status":"A","origin":"endogenous","substrate":"nascent PG","note_i18n":{"en":"Prefers nascent PG; 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not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"pbpClass":"C","noVegetativeModel":true,"evidenceSource":"review","citationScope":"R79 introduction lists 16 PBP classes; it does not independently assay all 16 reactions.","modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E179","species":"B. subtilis","name":"RodA","sites":["GT"],"activity":"SEDS peptidoglycan polymerase","refs":["R64"],"note":"","note_i18n":{"en":"","es":""},"status":"B","origin":"endogenous","substrate":"Lipid II / nascent PG","roles":["polymerase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":true,"extracellularRecovery":false}},{"id":"E180","species":"B. subtilis","name":"FtsW","sites":["GT"],"activity":"SEDS peptidoglycan polymerase","refs":["R65"],"note":"","note_i18n":{"en":"","es":""},"status":"B","origin":"endogenous","substrate":"Lipid II / nascent PG","roles":["polymerase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"evidenceSource":"inferred","modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":true,"extracellularRecovery":false}},{"id":"E181","species":"B. subtilis","name":"SpoVE","sites":["GT"],"activity":"SEDS peptidoglycan polymerase","refs":["R64"],"note":"","note_i18n":{"en":"","es":""},"status":"B","origin":"endogenous","substrate":"spore cortex synthesis","roles":["polymerase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":true,"evidenceSource":"inferred","modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E182","species":"B. subtilis","name":"LdcB","sites":["34"],"activity":"L,D-carboxypeptidase","refs":["R87"],"note":"LAS 家族四肽修剪酶；不要与芽孢 PBP5*/DacB 的 D,D 活性混淆。","note_i18n":{"en":"LAS-family tetrapeptide trimming; distinguish from the DD activity of spore PBP5*/DacB.","es":"Recorte de tetrapéptidos por la familia LAS; distinguir de la actividad DD de PBP5*/DacB de esporas."},"status":"A","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E183","species":"B. subtilis","name":"CwlA","sites":["A"],"activity":"NAM-L-Ala amidase","refs":["REF0172","REF0091"],"note":"1991 年原始论文摘要报告纯化 CwlA 的 MurNAc–L-Ala 酰胺酶活性；本次未复查原始图，范围限于文中底物，不外推到所有菌株。","note_i18n":{"en":"The 1991 primary abstract reports MurNAc–L-Ala amidase activity of purified CwlA. Original figures were not rechecked; the claim is limited to the studied substrate and does not cover every strain.","es":"El resumen primario de 1991 informa actividad amidasa MurNAc–L-Ala de CwlA purificada. No se revisaron las figuras originales; la afirmación se limita al sustrato estudiado y no abarca todas las cepas."},"status":"A","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase"],"aliases":["P24808","BSU25900"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"evidenceSource":"primary-biochem","sourceAccess":"abstract","locator":"Abstract: bond-specific characterization","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0172","sourceId":"BS-CwlA-1991","url":"https://pubmed.ncbi.nlm.nih.gov/1908396/","doi":"10.1016/0378-1097(91)90462-j","sourceAccess":"abstract","locator":"Abstract: bond-specific characterization","evidenceType":"direct_biochemical","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"direct","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E184","species":"B. subtilis","name":"CwlH","sites":["A"],"activity":"NAM-L-Ala amidase","refs":["REF0173","REF0091"],"note":"1999 年原始结果及图 3 的索引正文报告 L-Ala 氨基释放，支持 MurNAc–L-Ala 酰胺酶归属；访问范围为索引原文，未独立复查图像。","note_i18n":{"en":"Indexed primary Results and Figure 3 text from 1999 report release of L-Ala amino groups, supporting MurNAc–L-Ala amidase activity. The original figure image was not independently rechecked.","es":"El texto primario indexado de Resultados y Figura 3 de 1999 informa liberación de grupos amino de L-Ala y respalda la actividad amidasa MurNAc–L-Ala. No se revisó independientemente la imagen original."},"status":"A","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase"],"aliases":["P54450","BSU25710","yqeE"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"evidenceSource":"primary-biochem","sourceAccess":"indexed_excerpt","locator":"Results and Figure 3: cleavage specificity","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0173","sourceId":"BS-CwlH-1999","url":"https://journals.asm.org/doi/10.1128/JB.181.20.6230-6237.1999","doi":"10.1128/JB.181.20.6230-6237.1999","sourceAccess":"indexed_excerpt","locator":"Results and Figure 3: cleavage specificity","evidenceType":"direct_biochemical","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"direct","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E185","species":"B. subtilis","name":"XlyA","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["REF0174","REF0091"],"note":"1994 年原始摘要把 168/PBSX 的 XlyA 归为 MurNAc–L-Ala 酰胺酶，但本次未核实原始切键分析。保留类别归属，精确切点按候选处理并关闭动画；该噬菌体背景不代表所有菌株。","note_i18n":{"en":"The 1994 primary abstract assigns XlyA from 168/PBSX to the MurNAc–L-Ala amidase class, but its original bond analysis was not verified here. The site remains a candidate and animation is disabled; this phage context is not universal across strains.","es":"El resumen primario de 1994 asigna XlyA de 168/PBSX a la clase amidasa MurNAc–L-Ala, pero aquí no se verificó el análisis original del enlace. El sitio queda como candidato, sin animación; este contexto de fago no es universal entre cepas."},"status":"B","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["P39800","BSU12810"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"evidenceSource":"pending","sourceAccess":"abstract","locator":"Publisher abstract: XlyA biochemical identity","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0174","sourceId":"BS-XlyA-1994","url":"https://www.microbiologyresearch.org/content/journal/micro/10.1099/13500872-140-8-1855","doi":"10.1099/13500872-140-8-1855","sourceAccess":"abstract","locator":"Publisher abstract: XlyA biochemical identity","evidenceType":"primary_biochemical_assignment","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"candidate","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"candidateSites":["A"],"candidateReaction":"N-acetylmuramoyl-L-alanine amidase.","animate":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E186","species":"B. subtilis","name":"XlyB","sites":["A"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R91"],"note":"UniProt O34391 注释为酰胺酶；这是注释级归类，非本条原始生化切点确认。","note_i18n":{"en":"UniProt O34391 annotates an amidase; this is an annotation-level assignment, not a rechecked biochemical bond assay.","es":"UniProt O34391 anota una amidasa; es una asignación de anotación, no un ensayo bioquímico de enlace verificado aquí."},"status":"B","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["O34391","BSU12460","yjpB"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"animate":false,"evidenceSource":"inferred","siteEvidence":"annotation","modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E187","species":"B. subtilis","name":"BlyA","sites":["A"],"activity":"NAM-L-Ala amidase","refs":["REF0175","REF0091"],"note":"1998 年原始摘要报告纯化 BlyA 的 MurNAc–L-Ala 酰胺酶活性。限于所研究的 168/SPβ 背景；该目录研究的 PY79 不含此条目，不能当作全菌株共有蛋白。","note_i18n":{"en":"The 1998 primary abstract reports MurNAc–L-Ala amidase activity of purified BlyA in the studied 168/SPβ context. It is absent from the inventory study's PY79 strain and is not shared by all strains.","es":"El resumen primario de 1998 informa actividad amidasa MurNAc–L-Ala de BlyA purificada en el contexto 168/SPβ estudiado. Está ausente de la cepa PY79 del inventario y no se comparte entre todas las cepas."},"status":"A","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase"],"aliases":["O31982","BSU21410","yomC"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"evidenceSource":"primary-biochem","sourceAccess":"abstract","locator":"Primary abstract: purified BlyA activity","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0175","sourceId":"BS-BlyA-1998","url":"https://pubmed.ncbi.nlm.nih.gov/9579063/","doi":"10.1099/00221287-144-4-885","sourceAccess":"abstract","locator":"Primary abstract: purified BlyA activity","evidenceType":"direct_biochemical","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"direct","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E188","species":"B. subtilis","name":"CwlC","sites":["A"],"activity":"NAM-L-Ala amidase","refs":["REF0176","REF0091"],"note":"2000 年原始生化论文摘要报告 CwlC 酰胺酶的胞壁水解活性；范围为所测 A 型胞壁。本次只核查摘要，未重读具体切键定位图，不外推到所有胞壁类型。","note_i18n":{"en":"The 2000 primary biochemical abstract reports wall-hydrolytic activity of the CwlC amidase on the studied A-type walls. Access was abstract-level; the bond-localization figure was not re-read, and the claim does not cover all wall chemotypes.","es":"El resumen bioquímico primario de 2000 informa actividad hidrolítica de la amidasa CwlC sobre las paredes de tipo A estudiadas. El acceso fue al resumen; no se revisó la figura de localización del enlace ni se extrapola a todos los quimiotipos."},"status":"A","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase"],"aliases":["Q06320","BSU17410"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"evidenceSource":"primary-biochem","sourceAccess":"abstract","locator":"Abstract: characterized CwlC amidase activity","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0176","sourceId":"BS-CwlC-2000","url":"https://pubmed.ncbi.nlm.nih.gov/10945275/","doi":"10.1271/bbb.64.1522","sourceAccess":"abstract","locator":"Abstract: characterized CwlC amidase activity","evidenceType":"direct_biochemical_activity","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"direct","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E189","species":"B. subtilis","name":"CwlD","sites":["A"],"activity":"NAM-L-Ala amidase","refs":["REF0177","REF0091"],"note":"2023 年原文图 2 的产物分析支持 B. subtilis CwlD 从 MurNAc 去除肽干的酰胺酶反应。生理背景为芽孢皮层，直接化学证据采用线性 PG；不在通用营养体模型中播放。","note_i18n":{"en":"Product analysis in Figure 2 of the 2023 primary paper supports stem removal from MurNAc by B. subtilis CwlD. Its physiological context is spore cortex and the direct chemistry uses linear PG; no generic vegetative-wall animation is enabled.","es":"El análisis de productos de la Figura 2 del artículo primario de 2023 respalda la eliminación del tallo de MurNAc por CwlD de B. subtilis. 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The enzyme is from B. subtilis, but these chemical assays use E. coli PG and its cross-linked fragments. Those products are not native B. subtilis assignments; animation remains disabled.","es":"Morlot 2010 respalda las reacciones amidasa MurNAc–L-Ala y D,D-endopeptidasa de SpoIIP. La enzima procede de B. subtilis, pero los ensayos químicos usan PG de E. coli y sus fragmentos entrecruzados. Esos productos no son asignaciones nativas de B. subtilis; la animación permanece desactivada."},"status":"A","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase"],"aliases":["P37968","BSU25530"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"animate":false,"noVegetativeModel":true,"evidenceSource":"primary-biochem","sourceAccess":"indexed_excerpt","locator":"Results: IIP has amidase and endopeptidase activities; Figure 2C–H and Supplemental Figure S3","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0178","sourceId":"BS-SpoIIP-IID-2010","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2816739/","doi":"10.1101/gad.1878110","sourceAccess":"indexed_excerpt","locator":"Results: IIP has amidase and endopeptidase activities; Figure 2C–H and Supplemental Figure S3","evidenceType":"direct_biochemical_product_analysis","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"direct","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"assaySubstrateSpecies":"Escherichia coli","modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E195","species":"B. subtilis","name":"PBP4* / PbpE","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R91"],"note":"","note_i18n":{"en":"","es":""},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["P32959","BSU34440","PBP4*","pbpE"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"pbpClass":"C","noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E196","species":"B. subtilis","name":"PbpX","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R91"],"note":"","note_i18n":{"en":"","es":""},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["O31773","BSU16950","PBPX"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"pbpClass":"C","noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E197","species":"B. subtilis","name":"AmiE","sites":["A"],"activity":"NAM-L-Ala amidase","refs":["R91","R116"],"note":"识别已去除末端 GlcNAc 的 MurNAc-肽；不把完整 GlcNAc-MurNAc-肽画成已证实底物。","note_i18n":{"en":"Recognizes MurNAc-peptides after terminal GlcNAc removal. 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El sitio queda como candidato, sin animación."},"status":"B","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["O32108","BSU32070"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":true,"evidenceSource":"primary-biochem","sourceAccess":"indexed_excerpt","locator":"Results: +Anhydro product structure; Table 1; Conclusions","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0179","sourceId":"BS-YuiC-2015","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4499186/","doi":"10.1186/s12900-015-0039-z","sourceAccess":"indexed_excerpt","locator":"Results: +Anhydro product structure; Table 1; Conclusions","evidenceType":"direct_surrogate_product_structure","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"candidate","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"candidateSites":["M"],"candidateReaction":"Lytic-transglycosylase-like reaction with a directly observed 1,6-anhydro sugar product.","animate":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E206","species":"B. subtilis","name":"YorM","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R91"],"note":"不在该研究的 PY79 菌株中。","note_i18n":{"en":"Absent from the study's PY79 strain.","es":"Ausente en la cepa PY79 del estudio."},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["O31901","BSU20330"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E207","species":"B. subtilis","name":"YkvT","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R91"],"note":"","note_i18n":{"en":"","es":""},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["O31685","BSU13820"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E208","species":"B. subtilis","name":"XkdO","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R91"],"note":"","note_i18n":{"en":"","es":""},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["P54334","BSU12680"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E209","species":"B. subtilis","name":"CwlQ","sites":["M"],"activity":"Muramidase + lytic transglycosylase","refs":["REF0085","REF0091"],"note":"R85 的原始 HPLC/MS/MS 产物鉴定同时报告 MurNAc 和 1,6-anhydro-MurNAc，支持 CwlQ 的胞壁质酶与裂解性转糖基酶两种反应。水解产物与 anhydro 产物必须分开标注。","note_i18n":{"en":"Original product identification in R85 reports both MurNAc and 1,6-anhydro-MurNAc, supporting muramidase and lytic transglycosylase reactions of CwlQ. Hydrolytic and anhydro products must remain distinct.","es":"La identificación original de productos en R85 informa MurNAc y 1,6-anhidro-MurNAc, respaldando las reacciones muramidasa y transglicosilasa lítica de CwlQ. Los productos hidrolíticos y anhidro deben distinguirse."},"status":"A","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase","lyticTG"],"aliases":["O31608","BSU11570","yjbJ"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"productMode":"mixed","noVegetativeModel":false,"evidenceSource":"primary-biochem","sourceAccess":"abstract","locator":"Abstract: HPLC/MS/MS product identities","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0085","sourceId":"R85","url":"https://pubmed.ncbi.nlm.nih.gov/20609359/","doi":"10.1016/j.bbrc.2010.07.001","sourceAccess":"abstract","locator":"Abstract: HPLC/MS/MS product identities","evidenceType":"direct_biochemical_product_analysis","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"direct","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E210","species":"B. subtilis","name":"YqbO","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R91"],"note":"","note_i18n":{"en":"","es":""},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["P45931","BSU26030"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E211","species":"B. subtilis","name":"CwlP","sites":["M","43"],"activity":"Muramidase + D,D-endopeptidase","refs":["REF0107","REF0091"],"note":"R107 的原始产物分析支持 CwlP 的胞壁质酶和 D-Ala–DAP 交联 D,D-内肽酶反应。其名为 SLT 的结构域实际归为胞壁质酶，不能据结构域名称显示 anhydro 产物。","note_i18n":{"en":"Original product analysis in R107 supports CwlP muramidase activity and D,D-endopeptidase cleavage of D-Ala–DAP cross-links. The domain named SLT is a muramidase here; its domain name does not justify an anhydro product.","es":"El análisis original de productos en R107 respalda la actividad muramidasa de CwlP y el corte D,D-endopeptidasa de enlaces D-Ala–DAP. El dominio llamado SLT es aquí una muramidasa; su nombre no justifica un producto anhidro."},"status":"A","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase"],"aliases":["O31976","BSU21350","yomI"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"evidenceSource":"primary-biochem","sourceAccess":"full_text","locator":"Abstract; Results product analysis and Figures 2–3","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0107","sourceId":"R107","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3009849/","doi":"10.1074/jbc.M110.156273","sourceAccess":"full_text","locator":"Abstract; Results product analysis and Figures 2–3","evidenceType":"direct_biochemical_product_analysis","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"direct","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E212","species":"B. subtilis","name":"YocA","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R91"],"note":"","note_i18n":{"en":"","es":""},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["O34636","BSU19130"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E213","species":"B. subtilis","name":"CwlT","sites":["M","23"],"activity":"Muramidase + D,L-endopeptidase","refs":["REF0180","REF0091"],"note":"Fukushima 2008 的原始摘要分别确认 CwlT 的 D-γ-Glu–meso-DAP 内肽酶反应和胞壁质酶产物，并排除后者为裂解性转糖反应。限于 B. subtilis 的酶与底物；该目录研究的 PY79 不含此条目。","note_i18n":{"en":"Fukushima 2008 separately identifies D-γ-Glu–meso-DAP cleavage and muramidase products for CwlT, explicitly excluding a lytic transglycosylase assignment for the glycan reaction. Evidence concerns the B. subtilis enzyme and substrate; this entry is absent from the inventory study's PY79 strain.","es":"Fukushima 2008 identifica por separado el corte D-γ-Glu–meso-DAP y productos de muramidasa de CwlT, excluyendo una transglicosilasa lítica para la reacción del glicano. La evidencia corresponde a la enzima y sustrato de B. subtilis; este registro está ausente de PY79 en el estudio del inventario."},"status":"A","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase"],"aliases":["P96645","BSU04970","yddH"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"evidenceSource":"primary-biochem","sourceAccess":"abstract","locator":"Abstract: C-terminal bond assignment and N-terminal product analysis","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0180","sourceId":"BS-CwlT-2008","url":"https://pubmed.ncbi.nlm.nih.gov/18305117/","doi":"10.1074/jbc.M706626200","sourceAccess":"abstract","locator":"Abstract: C-terminal bond assignment and N-terminal product analysis","evidenceType":"direct_biochemical_product_analysis","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"direct","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E214","species":"B. subtilis","name":"YdjM","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R91"],"note":"","note_i18n":{"en":"","es":""},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["P40775","BSU06250","yzvA"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E215","species":"B. subtilis","name":"YoaJ","sites":[],"activity":"PG-associated protein; not an established PG-cleaving enzyme","refs":["R91"],"note":"文献检索命中或相关蛋白；此记录不表示具有直接 PG 水解活性。 不在该研究的 PY79 菌株中。","note_i18n":{"en":"Domain-screen hit or associated protein; this record does not assert direct PG hydrolysis. Absent from the study's PY79 strain.","es":"Proteína asociada o detectada por dominio; no se afirma hidrólisis directa del PG. Ausente en la cepa PY79 del estudio."},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["associated"],"aliases":["O34918","BSU18630","EXLX1"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E216","species":"B. subtilis","name":"SpoIID","sites":["M"],"activity":"lytic transglycosylase","refs":["REF0178","REF0091"],"note":"Morlot 2010 支持 SpoIID 的裂解性转糖反应，但底物必须先去除肽干（denuded PG）。不能把带完整肽干的通用营养体糖链当成已确认底物；关闭该模型动画。","note_i18n":{"en":"Morlot 2010 supports SpoIID lytic transglycosylase activity only on PG whose peptide stems have been removed (denuded PG). A generic stem-bearing vegetative glycan is not a verified substrate; that model's animation is disabled.","es":"Morlot 2010 respalda la actividad transglicosilasa lítica de SpoIID únicamente sobre PG sin tallos peptídicos. Un glicano vegetativo genérico con tallos no es un sustrato verificado; la animación de ese modelo queda desactivada."},"status":"A","origin":"endogenous","substrate":"denuded PG","roles":["lyticTG"],"aliases":["P07372","BSU36750","spoIIC"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"animate":false,"noVegetativeModel":true,"evidenceSource":"primary-biochem","sourceAccess":"abstract","locator":"Abstract: SpoIID glycan products and substrate requirement","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0178","sourceId":"BS-SpoIIP-IID-2010","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2816739/","doi":"10.1101/gad.1878110","sourceAccess":"abstract","locator":"Abstract: SpoIID glycan products and substrate requirement","evidenceType":"direct_biochemical_product_analysis","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"direct","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E217","species":"B. subtilis","name":"LytB","sites":[],"activity":"PG-associated protein; not an established PG-cleaving enzyme","refs":["R91"],"note":"文献检索命中或相关蛋白；此记录不表示具有直接 PG 水解活性。","note_i18n":{"en":"Domain-screen hit or associated protein; this record does not assert direct PG hydrolysis.","es":"Proteína asociada o detectada por dominio; no se afirma hidrólisis directa del PG."},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["associated"],"aliases":["Q02113","BSU35630","cwbA"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E218","species":"B. subtilis","name":"SweC","sites":[],"activity":"PG-associated protein; not an established PG-cleaving enzyme","refs":["R91"],"note":"文献检索命中或相关蛋白；此记录不表示具有直接 PG 水解活性。","note_i18n":{"en":"Domain-screen hit or associated protein; this record does not assert direct PG hydrolysis.","es":"Proteína asociada o detectada por dominio; no se afirma hidrólisis directa del PG."},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["associated"],"aliases":["O32023","BSU24940","yqzC"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E219","species":"B. subtilis","name":"PgdS","sites":[],"activity":"PG-associated protein; not an established PG-cleaving enzyme","refs":["R91"],"note":"非肽聚糖底物：PgdS（YwtD）降解聚 γ-谷氨酸，不列为 PG 切割酶。","note_i18n":{"en":"Non-PG substrate: PgdS (YwtD) degrades poly-γ-glutamate and is not a PG-cleaving enzyme.","es":"Sustrato ajeno al PG: PgdS (YwtD) degrada poli-γ-glutamato; no es una enzima de corte del PG."},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["associated"],"aliases":["P96740","BSU35860","ywtD"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":true,"animate":false,"nonPGSubstrate":true,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E220","species":"B. subtilis","name":"YkfC","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["REF0181","REF0091"],"note":"YkfC 的原始候选来源是 Schmidt 2001，但本次无法访问其反应部分；精确底物与 2–3 切点仍待核查。B. cereus 的 YkfC 结构以及 Xu 2009 的其他物种蛋白不能替代 B. subtilis 的直接证据；仅保留游离肽回收候选，关闭动画。","note_i18n":{"en":"Schmidt 2001 is the candidate original source for YkfC, but its reaction section was inaccessible here; substrate scope and the 2–3 site remain unverified. B. cereus YkfC structures and proteins from other species in Xu 2009 do not establish B. subtilis activity. Retain a free-peptide recycling candidate without animation.","es":"Schmidt 2001 es la fuente original candidata para YkfC, pero aquí no fue accesible su sección de reacción; el sustrato y el sitio 2–3 siguen sin verificar. Las estructuras de YkfC de B. cereus y proteínas de otras especies en Xu 2009 no establecen la actividad de B. subtilis. Se conserva una candidata de reciclaje de péptidos libres, sin animación."},"status":"B","origin":"endogenous","substrate":"free peptide recycling intermediates","roles":["candidate"],"aliases":["O35010","BSU12990"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":true,"evidenceSource":"pending","sourceAccess":"unavailable","locator":"Candidate original paper identified in citations; original reaction section inaccessible","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0181","sourceId":"BS-YkfC-2001-candidate","url":"https://pubs.acs.org/doi/10.1021/bi011640x","doi":"10.1021/bi011640x","sourceAccess":"unavailable","locator":"Candidate original paper identified in citations; original reaction section inaccessible","evidenceType":"candidate_primary_not_verified","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"candidate","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"candidateSites":["23"],"candidateReaction":"Candidate γ-D-Glu–L-diamino-acid peptide cleavage; exact B. subtilis substrate scope not independently verified here.","animate":false,"modelTraits":{"recycling":true,"freePeptide":true,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E221","species":"B. subtilis","name":"YqgT","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R91"],"note":"","note_i18n":{"en":"","es":""},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["P54497","BSU24830"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E222","species":"B. subtilis","name":"YycO","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R91"],"note":"","note_i18n":{"en":"","es":""},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["Q45607","BSU40280"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E223","species":"B. subtilis","name":"CwlK","sites":["12"],"activity":"L-Ala–D-Glu endopeptidase","refs":["REF0182","REF0091"],"note":"Fukushima 2007 原始摘要把 CwlK 定为切开 L-Ala–D-Glu 的 L,D-内肽酶，区别于 D-Ala–D-Ala 羧肽酶归属。此处确认的是肽干内部 1–2 键，不是肽干之间的交联。","note_i18n":{"en":"The Fukushima 2007 primary abstract identifies CwlK as an L,D-endopeptidase cleaving L-Ala–D-Glu, distinct from a D-Ala–D-Ala carboxypeptidase assignment. 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Es el enlace 1–2 dentro del tallo, no un entrecruzamiento entre tallos."},"status":"A","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase"],"aliases":["O34360","BSU02810","ycdD"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"evidenceSource":"primary-biochem","sourceAccess":"abstract","locator":"Abstract: specific bond characterization","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0182","sourceId":"BS-CwlK-2007","url":"https://pubmed.ncbi.nlm.nih.gov/17588176/","doi":"10.1007/s00438-007-0255-8","sourceAccess":"abstract","locator":"Abstract: specific bond characterization","evidenceType":"direct_biochemical","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"direct","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; the inventory is not the original bond-cleavage evidence for these entries.","es":"Exhaustive en R91 se refiere al inventario definido por ese estudio, no a todas las hidrolasas o cepas; el inventario no es la evidencia original de corte de estos enlaces."},"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E224","species":"B. subtilis","name":"LytH","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["REF0108","REF0091"],"note":"Horsburgh 2003 根据芽孢皮层 PG 的遗传与组分变化推断 LytH 的 L-Ala–D-Glu 内肽酶作用；这不是本次已核实的纯化酶切键证据。保留 B 级、候选 1–2 位点和芽孢皮层范围，关闭动画。","note_i18n":{"en":"Horsburgh 2003 infers an L-Ala–D-Glu endopeptidase role for LytH from genetic and spore-cortex PG composition changes. This is not a verified purified-enzyme bond assay in this audit. Retain B, a candidate 1–2 site, and the spore-cortex boundary without animation.","es":"Horsburgh 2003 infiere una función endopeptidasa L-Ala–D-Glu de LytH a partir de cambios genéticos y de composición del PG de la corteza de espora. No es un ensayo de corte con enzima purificada verificado en esta revisión. Se mantienen B, el sitio candidato 1–2 y el ámbito de corteza de espora, sin animación."},"status":"B","origin":"endogenous","substrate":"spore cortex","roles":["candidate"],"aliases":["O32130","BSU32340","yunA","yutA"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":true,"evidenceSource":"genetic","sourceAccess":"abstract","locator":"Abstract; source cortex muropeptide comparison","evidenceReferences":[{"ref":"REF0091","sourceId":"R91","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10653849/","doi":"10.1128/mbio.01760-23","sourceAccess":"indexed_excerpt","locator":"Table 1 caption and indexed abstract","evidenceType":"inventory_and_genetics","role":"inventory"},{"ref":"REF0108","sourceId":"R108","url":"https://pubmed.ncbi.nlm.nih.gov/12813075/","doi":"10.1128/JB.185.13.3813-3820.2003","sourceAccess":"abstract","locator":"Abstract; source cortex muropeptide comparison","evidenceType":"genetic_composition_inference","role":"reaction_evidence"}],"evidenceChecked":"2026-11-07","evidenceAudit":"research/product-recheck-2026-11-07/bacillus-enzyme-evidence.json","siteEvidence":"candidate","inventoryScope":{"zh":"R91 中的 exhaustive 指该研究界定的清单，不代表所有已知水解酶或所有菌株；该目录不是这些条目的原始切键证据。","en":"Exhaustive in R91 refers to that study's defined inventory, not every known hydrolase or strain; 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CHAP-related candidates are listed individually; a domain alone does not establish bond specificity.","es":"Nombre de locus N315. Candidatos CHAP separados; el dominio no demuestra la especificidad del enlace."},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":["N315 SA2332"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E301","species":"E. faecalis","name":"SalA","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R114"],"note":"已报道交联片段的肽桥区域切割；此处未确定具体哪一条键，不画成肽干切点。","note_i18n":{"en":"Reported cleavage within the cross-bridge region of a crosslinked fragment; the exact bond is not assigned here and is not depicted as a stem cut.","es":"Se describió corte en la región del puente de un fragmento entrecruzado; aquí no se asigna el enlace exacto ni se representa como corte del tallo."},"status":"B","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase","candidate"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E302","species":"E. faecalis","name":"SalB","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R114"],"note":"该研究未检测到 PG 水解；不将单一检测中的阴性结果解释为所有条件下无活性。","note_i18n":{"en":"PG hydrolysis was not detected in this study; that result does not establish inactivity under all conditions.","es":"No se detectó hidrólisis de PG en ese estudio; esto no demuestra inactividad en todas las condiciones."},"status":"P","origin":"endogenous","substrate":"PG / muropeptide","roles":["candidate"],"aliases":[],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E303","species":"S. mutans","name":"LytF","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","refs":["R115"],"note":"有 PG 水解功能证据，精确切键未在此处确认；与其他菌种同名蛋白分别收录。","note_i18n":{"en":"PG hydrolase function is supported; the precise bond is not resolved here. Listed separately from same-named proteins in other species.","es":"Hay evidencia de función hidrolasa de PG; el enlace preciso no está resuelto aquí. Se distingue de proteínas homónimas de otras especies."},"status":"B","origin":"endogenous","substrate":"PG / muropeptide","roles":["hydrolase","candidate"],"aliases":["SMU.836","LytFSm"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E304","species":"B. subtilis","name":"NamZ","sites":["M"],"activity":"N-acetylmuramidase","refs":["R117"],"note":"外切胞壁质酶；此图采用已表征的 MurNAc–GlcNAc 二糖底物，不附加肽干。","note_i18n":{"en":"Exo-muramidase. This diagram uses the characterized MurNAc–GlcNAc disaccharide substrate, without peptide stems.","es":"Exo-muramidasa. El esquema usa el disacárido MurNAc–GlcNAc caracterizado, sin tallos peptídicos."},"status":"A","origin":"endogenous","substrate":"MurNAc-beta1,4-GlcNAc","roles":["hydrolase"],"aliases":["YbbC"],"entryType":"protein","scope":{"zh":"所列菌种；不自动外推到全部菌株","en":"Listed species; not automatically universal across strains","es":"Especie indicada; no se extrapola a todas las cepas"},"model":"disaccharideMN","noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E305","species":"E. coli","name":"FtsE","sites":[],"activity":"PG-associated protein; not an established PG-cleaving enzyme","roles":["associated"],"status":"B","note":"FtsEX 调控系统的 ATPase 亚基；不直接切 PG，FtsEX–EnvC 调节酰胺酶激活。","note_i18n":{"en":"ATPase subunit of the FtsEX regulatory system. It does not cleave PG directly; FtsEX–EnvC regulates amidase activation.","es":"Subunidad ATPasa de FtsEX. No corta PG directamente; FtsEX–EnvC regula la activación de amidasas."},"refs":["R118"],"aliases":[],"entryType":"protein","origin":"endogenous","substrate":"PG / muropeptide","animate":false,"scope":{"en":"Activity limited to the cited substrates and source species.","zh":"活性限定于文献所述底物和来源物种。","es":"Actividad limitada a los sustratos y la especie citados."},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E306","species":"E. coli","name":"FtsX","sites":[],"activity":"PG-associated protein; not an established PG-cleaving enzyme","roles":["associated"],"status":"B","note":"FtsEX 的膜组分，介导与 EnvC 的调控联系；不为 FtsX 指定 PG 断键。","note_i18n":{"en":"Membrane component of FtsEX; transmits regulatory interactions with EnvC. No PG cleavage bond is assigned to FtsX.","es":"Componente de membrana de FtsEX que media interacciones reguladoras con EnvC. No se le asigna un corte de PG."},"refs":["R118"],"aliases":[],"entryType":"protein","origin":"endogenous","substrate":"PG / muropeptide","animate":false,"scope":{"en":"Activity limited to the cited substrates and source species.","zh":"活性限定于文献所述底物和来源物种。","es":"Actividad limitada a los sustratos y la especie citados."},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E307","species":"E. coli","name":"EnvC","sites":[],"activity":"PG-associated protein; not an established PG-cleaving enzyme","roles":["associated"],"status":"B","note":"与 FtsEX 相关的酰胺酶激活因子；调控激活不能画成 EnvC 自身水解肽键。","note_i18n":{"en":"Amidase activator associated with FtsEX. Regulatory activation must not be displayed as EnvC peptide hydrolysis.","es":"Activador de amidasas asociado a FtsEX. La activación reguladora no debe representarse como hidrólisis peptídica por EnvC."},"refs":["R118"],"aliases":[],"entryType":"protein","origin":"endogenous","substrate":"PG / muropeptide","animate":false,"scope":{"en":"Activity limited to the cited substrates and source species.","zh":"活性限定于文献所述底物和来源物种。","es":"Actividad limitada a los sustratos y la especie citados."},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E308","species":"A. baumannii","name":"AmpG1","sites":[],"activity":"PG-associated protein; not an established PG-cleaving enzyme","roles":["associated"],"status":"B","note":"2026 年研究中与 Slt 相关的胞壁肽通透酶；AmpG1 负责转运，LT 催化活性归于 Slt。已核对索引摘要。","note_i18n":{"en":"Muropeptide permease linked to Slt in the 2026 study. AmpG1 transports; the LT catalytic activity belongs to Slt. Indexed abstract checked.","es":"Permeasa de muropéptidos vinculada a Slt en 2026. AmpG1 transporta; la catálisis LT corresponde a Slt. Se verificó el resumen indexado."},"refs":["R120"],"aliases":[],"entryType":"protein","origin":"endogenous","substrate":"PG / muropeptide","animate":false,"scope":{"en":"Activity limited to the cited substrates and source species.","zh":"活性限定于文献所述底物和来源物种。","es":"Actividad limitada a los sustratos y la especie citados."},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E309","species":"B. bifidum","name":"BbMep","sites":["23"],"activity":"D,L-endopeptidase","roles":["hydrolase"],"status":"A","note":"在受测 Lys/Orn 底物切肽干 2–3；受测未交联单体不是底物。菌囊释放可溶性糖二肽需要胞壁质酶步骤；暂无物种匹配动画。","note_i18n":{"en":"Cuts stem 2–3 in tested Lys/Orn-type substrates. Tested non-crosslinked monomers were not substrates. Soluble glycan-dipeptide release from sacculi needs a muramidase step; no species-matched animation is available.","es":"Corta el enlace 2–3 en sustratos Lys/Orn ensayados. Los monómeros no entrecruzados probados no fueron sustratos. La liberación soluble requiere una muramidasa; no hay animación específica."},"refs":["R123"],"aliases":["A0A286TC91"],"entryType":"protein","origin":"endogenous","substrate":"PG / muropeptide","animate":false,"scope":{"en":"Activity limited to the cited substrates and source species.","zh":"活性限定于文献所述底物和来源物种。","es":"Actividad limitada a los sustratos y la especie citados."},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E310","species":"B. adolescentis","name":"BaMep","sites":["U"],"activity":"PG-active domain candidate; precise reaction unresolved","roles":["candidate"],"status":"P","note":"NlpC/p60 同源蛋白；2025 年研究未显示类似 BbMep 的二肽/末端肽产物增加。同源性不能代替 D,L-内肽酶活性证明。","note_i18n":{"en":"NlpC/p60 homolog. The 2025 study did not demonstrate the BbMep-like increase in dipeptide/terminal-peptide products. Homology is not established D,L-endopeptidase activity.","es":"Homólogo NlpC/p60. El estudio de 2025 no demostró el aumento de productos dipeptídicos/terminales observado con BbMep. La homología no establece actividad D,L-endopeptidasa."},"refs":["R123"],"aliases":["A1A0D3"],"entryType":"protein","origin":"endogenous","substrate":"PG / muropeptide","animate":false,"scope":{"en":"Activity limited to the cited substrates and source species.","zh":"活性限定于文献所述底物和来源物种。","es":"Actividad limitada a los sustratos y la especie citados."},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E311","species":"S. pettenkoferi","name":"SpM23_B SH3b domain","sites":[],"activity":"PG-associated protein; not an established PG-cleaving enzyme","roles":["associated"],"status":"B","note":"2026 年文章研究的独立细胞壁结合域；抗菌效应不证明特定 PG 断键，不能等同于完整 SpM23_B 水解酶。","note_i18n":{"en":"Isolated cell-wall-binding domain studied in the 2026 article. Antimicrobial effects do not establish a specific PG bond cleavage. Do not equate the domain with the complete SpM23_B hydrolase.","es":"Dominio aislado de unión a pared estudiado en 2026. Los efectos antimicrobianos no establecen un corte específico de PG; no equivale a la hidrolasa completa SpM23_B."},"refs":["R119"],"aliases":["CBD_Sp_B"],"entryType":"domain","origin":"endogenous","substrate":"PG / muropeptide","animate":false,"scope":{"en":"Activity limited to the cited substrates and source species.","zh":"活性限定于文献所述底物和来源物种。","es":"Actividad limitada a los sustratos y la especie citados."},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}},{"id":"E312","species":"L. rhamnosus","name":"Msp1","sites":["23"],"activity":"D,L-endopeptidase","roles":["hydrolase"],"status":"A","note":"GG 菌株：切肽干 D-Gln–Lys；原文区分 mutanolysin 单酶与另加 Msp1，切肽归于 Msp1。","note_i18n":{"en":"GG strain: D-Gln–Lys stem cleavage. The original paper separates mutanolysin alone from mutanolysin plus Msp1; peptide cleavage belongs to Msp1.","es":"Cepa GG: corte D-Gln–Lys del tallo. El artículo distingue mutanolisina sola de mutanolisina más Msp1; el corte peptídico corresponde a Msp1."},"refs":["R138"],"aliases":["p75"],"entryType":"protein","origin":"endogenous","substrate":"PG / muropeptide","animate":false,"scope":{"en":"Activity limited to the cited substrates and source species.","zh":"活性限定于文献所述底物和来源物种。","es":"Actividad limitada a los sustratos y la especie citados."},"noVegetativeModel":false,"modelTraits":{"recycling":false,"freePeptide":false,"tripeptide":false,"nascent":false,"extracellularRecovery":false}}],"plates":[{"slug":"staph","title":"金黄色葡萄球菌","latin":"S. aureus","x":"L-Lys","bridge":["Gly","Gly","Gly","Gly","Gly"],"cross":"43","enzspecies":["S. aureus"],"synth":"FemX/FmhB + FemA + FemB: Gly桥；PBP2、FtsW-PBP1、RodA-PBP3：聚合/交联","notes":["Gly1定义为最靠近受体Lys的Gly；桥的游离N端靠近供体。\nLytM：同时标BR和43；LytH：标A，且偏好未交联PG。\nIsaA/SceD的LT判定保留为候选；SpdC/ActH不画切割箭头。"],"refs":["R02","R03","R04","R05","R06","R07","R08","R09","R10"],"gln":true,"modified":"","unknown":false,"i18n":{"en":{"title":"Staphylococcus aureus","synth":"FemX/FmhB, FemA and FemB assemble Gly5; PBP2, FtsW–PBP1 and RodA–PBP3 polymerize/crosslink PG.","notes":["Gly1 is nearest acceptor Lys. LytM acts at BR and 43; LytH at A, preferentially on uncrosslinked PG. IsaA/SceD remain putative LTs. SpdC/ActH are partners, not cleavage sites."]},"es":{"title":"Staphylococcus aureus","synth":"FemX/FmhB, FemA y FemB ensamblan Gly5; PBP2, FtsW–PBP1 y RodA–PBP3 polimerizan/entrecruzan PG.","notes":["Gly1 está junto a Lys aceptora. LytM actúa en BR y 43; LytH en A, preferentemente en PG sin entrecruzar. IsaA/SceD siguen siendo LT propuestas. SpdC/ActH son proteínas asociadas."]}},"chemotype":"A3α","chemotypeReview":{"kind":"existing_plate","plateSlug":"staph","chemotype":"A3α","dsmzCode":"A11.2","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"The displayed Gly5 bridge belongs to A3α; DSM 20231 is an official A11.2 example.","zh":"所画 Gly5 桥属于 A3α；DSM 20231 是官方 A11.2 实例。","es":"El puente Gly5 mostrado pertenece a A3α; DSM 20231 es un ejemplo oficial de A11.2."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A11.2","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A11.2","access":"full_text","role":"official_nomenclature"},{"id":"DSM20231","url":"https://www.dsmz.de/collection/catalogue/details/culture/DSM-20231","locator":"Strain summary, Murein A11.2","access":"indexed_excerpt","role":"official_strain_example"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"L-Lys","bridgeFromAcceptor":["Gly","Gly","Gly","Gly","Gly"],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0199","REF0200"]}},{"slug":"faecalis","title":"粪肠球菌","latin":"E. faecalis","x":"L-Lys","bridge":["L-Ala","L-Ala"],"cross":"43","enzspecies":["E. faecalis"],"synth":"BppA1/BppA2：Ala2桥；RodA-PbpA、FtsW-PbpB与aPBP：PG合成","notes":["AtlA切G；AtlB、AtlC、AtlE切M。\nEnpA切供体D-Ala与桥末端L-Ala的连接键；它是前噬菌体相关条目。\nAla2是典型桥；部分文献/菌株报告Ala2-3。"],"refs":["R11","R12","R13","R14","R15","R20"],"gln":true,"modified":"","unknown":false,"i18n":{"en":{"title":"Enterococcus faecalis","synth":"BppA1/BppA2 assemble Ala2 bridges; RodA–PbpA, FtsW–PbpB and aPBPs synthesize PG.","notes":["AtlA cleaves G; AtlB/C/E cleave M. Prophage-associated EnpA cleaves the D-Ala–terminal L-Ala junction. Ala2 is typical; Ala2–3 occurs in some reports/strains."]},"es":{"title":"Enterococcus faecalis","synth":"BppA1/BppA2 ensamblan puentes Ala2; RodA–PbpA, FtsW–PbpB y aPBP sintetizan PG.","notes":["AtlA corta G; AtlB/C/E cortan M. EnpA, asociada a profago, corta la unión D-Ala–L-Ala terminal. Ala2 es típico; algunas fuentes/cepas presentan Ala2–3."]}},"chemotype":"A3α","chemotypeReview":{"kind":"existing_plate","plateSlug":"faecalis","chemotype":"A3α","dsmzCode":"A11.5","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"The displayed Ala2 subgroup maps to A3α. This label does not fix bridge length in every strain.","zh":"所画 Ala2 亚型对应 A3α；此分型不能规定所有菌株的桥长。","es":"El subgrupo Ala2 mostrado corresponde a A3α; la clase no fija la longitud del puente de todas las cepas."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, rows A11.5–A11.6","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, rows A11.5–A11.6","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"L-Lys","bridgeFromAcceptor":["L-Ala","L-Ala"],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}},{"slug":"faecium","title":"屎肠球菌：D,D交联","latin":"E. faecium","x":"L-Lys","bridge":["D-iAsx"],"cross":"43","enzspecies":["E. faecium"],"synth":"Aslfm：D-Asp支链；PBP系统（含PBP5）：4→3交联","notes":["D-iAsx表示β连接D-Asp / D-isoAsn；酰胺化程度不是固定值。\nSagA切肽干内部的D-isoGln2-L-Lys3，不直接切D-Asx桥。\n保留桥的羧基连接方向；图中残基节点不展开所有原子。"],"refs":["R16","R17","R18","R21"],"gln":true,"modified":"","unknown":false,"i18n":{"en":{"title":"Enterococcus faecium · D,D","synth":"Aslfm adds D-Asp branches; the PBP system, including PBP5, forms 4–3 links.","notes":["D-iAsx denotes beta-linked D-Asp/D-isoAsn; amidation varies. SagA cleaves stem D-isoGln2–L-Lys3, not the D-Asx bridge. Nodes simplify atomic connectivity."]},"es":{"title":"Enterococcus faecium · D,D","synth":"Aslfm añade ramas D-Asp; el sistema PBP, incluida PBP5, forma enlaces 4–3.","notes":["D-iAsx indica D-Asp/D-isoAsn unido por beta; la amidación varía. SagA corta D-isoGln2–L-Lys3 del tallo, no el puente D-Asx. Los nodos simplifican los átomos."]}},"chemotype":"A4α","chemotypeReview":{"kind":"existing_plate","plateSlug":"faecium","chemotype":"A4α","dsmzCode":"A11.31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A4α applies to the displayed dicarboxylic-residue bridge family; Asp versus Asn requires the individual source.","zh":"A4α 对应所画二羧基氨基酸桥家族；Asp 与 Asn 的区分仍须依据具体来源。","es":"A4α corresponde a la familia de puentes de residuo dicarboxílico mostrada; Asp frente a Asn exige una fuente específica."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A11.31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A11.31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"L-Lys","bridgeFromAcceptor":["D-iAsx"],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","dsmzCodeScope":"A11.31 is the D-Asp representative. The displayed Asx shorthand does not independently resolve Asp/Asn or amidation.","officialExample":"DSM 2146 appears in DSMZ row A11.31; not a declaration that every E. faecium product has the same amidation state.","sourceIds":["REF0198","REF0200"]}},{"slug":"faecium_ld","title":"屎肠球菌：L,D交联","latin":"E. faecium","x":"L-Lys","bridge":["D-iAsn"],"cross":"33","enzspecies":["E. faecium"],"synth":"Ldtfm：3→3交联；供体来自四肽并释放D-Ala4","notes":["3→3也可以经桥发生，不等于“两个DAP直接相连”。\n所画为经D-iAsn受体的Ldtfm反应结构；不代表所有菌株以此为主。\n交联供体只有前三位；不得仍保留供体D-Ala4。"],"refs":["R18"],"gln":true,"modified":"","unknown":false,"i18n":{"en":{"title":"Enterococcus faecium · L,D","synth":"Ldtfm forms 3–3 links from a tetrapeptide donor, releasing D-Ala4.","notes":["3–3 links can also pass through a bridge. This D-iAsn-acceptor model does not mean all strains predominantly use this link. The mature donor has only positions 1–3."]},"es":{"title":"Enterococcus faecium · L,D","synth":"Ldtfm forma enlaces 3–3 a partir de un donante tetrapéptido, liberando D-Ala4.","notes":["Los enlaces 3–3 también pueden pasar por un puente. Este modelo con D-iAsn no implica predominio en todas las cepas. El donante maduro conserva solo las posiciones 1–3."]}},"chemotype":null,"chemotypeReview":{"kind":"existing_plate","plateSlug":"faecium_ld","chemotype":null,"dsmzCode":null,"checked":"2026-11-07","reviewStatus":"outside_displayed_classic_scheme","scope":{"en":"The displayed 3→3 linkage only; retain a separate topology label.","zh":"仅针对所画 3→3 连接；保留独立拓扑标签。","es":"Solo el enlace 3→3 mostrado; conservar una etiqueta de topología separada."},"note":{"en":"Keep the displayed 3→3 topology separately annotated. No classical 4→3 chemotype code is assigned to this linkage.","zh":"所画 3→3 拓扑单独标注；不把经典 4→3 分型号套在此连接上。","es":"Mantener la topología 3→3 mostrada como anotación separada; no asignarle un código clásico de enlace 4→3."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A classification boundaries; displayed 3→3 topology left unclassified","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A classification boundaries; displayed 3→3 topology left unclassified","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"L-Lys","bridgeFromAcceptor":["D-iAsn"],"crosslink":"3→3"},"diagramAction":"label_only_do_not_change_bonds","classicalContext":{"chemotype":"A4α","appliesTo":"Corresponding 4→3 structural subgroup only, if independently documented; not this 3→3 diagram."},"sourceIds":["REF0198","REF0200"]}},{"slug":"pneumo","title":"肺炎链球菌：带桥型","latin":"S. pneumoniae","x":"L-Lys","bridge":["L-Ser","L-Ala"],"cross":"43","enzspecies":["S. pneumoniae"],"synth":"MurM先加Ser或Ala、MurN再加Ala；FtsW-PBP2x / RodA-PBP2b","notes":["这里从受体Lys向外画Ser→Ala；Ala→Ala也是常见支链。\n无桥直接4→3与带桥型并存；不能把每个亚基画成带桥。\nPcsB不强行标成已确定的内肽酶切点。"],"refs":["R22","R23","R24","R25","R74"],"gln":true,"modified":"","unknown":false,"i18n":{"en":{"title":"Pneumococcus · bridged","synth":"MurM adds Ser or Ala, then MurN adds Ala; FtsW–PBP2x / RodA–PBP2b build PG.","notes":["From Lys outward the bridge is Ser–Ala or Ala–Ala. Direct and bridged 4–3 links coexist. PcsB is not assigned a definite bond."]},"es":{"title":"Neumococo · con puente","synth":"MurM añade Ser o Ala y MurN añade Ala; FtsW–PBP2x / RodA–PBP2b construyen PG.","notes":["Desde Lys hacia fuera el puente es Ser–Ala o Ala–Ala. Coexisten enlaces 4–3 directos y con puente. PcsB no tiene un enlace definitivo asignado."]}},"chemotype":"A3α","chemotypeReview":{"kind":"existing_plate","plateSlug":"pneumo","chemotype":"A3α","dsmzCode":"A11.18","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A3α describes only the displayed bridged subgroup. Keep direct and other branch assignments separate.","zh":"A3α 只描述所画有桥亚型；直接交联及其他支链须分别保留。","es":"A3α describe solo el subgrupo con puente mostrado; los enlaces directos y otras ramas deben mantenerse separados."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A11.18","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A11.18","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"L-Lys","bridgeFromAcceptor":["L-Ser","L-Ala"],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}},{"slug":"strepto","title":"其他常见链球菌：Ala桥型","latin":"S. pyogenes / S. agalactiae / S. mutans","x":"L-Lys","bridge":["L-Ala","L-Ala"],"cross":"43","enzspecies":["S. pyogenes","S. agalactiae","S. mutans"],"synth":"Mur/Fem类支链装配和PBP/SEDS系统；具体同源酶需逐菌种确认","notes":["图示Ala2；无乳链球菌还可有含Ser桥，变异链球菌可见Ala2-3。\n不是全部链球菌共用一套水解酶：CdhA、PcsB、GbpB分别保留。\nPlyPy属于外源噬菌体酶，见外源酶页。"],"refs":["R26","R27","R28"],"gln":true,"modified":"","unknown":false,"i18n":{"en":{"title":"Streptococci · Ala bridges","synth":"Mur/Fem-type branch assembly and PBP/SEDS systems; verify homologues by species.","notes":["Ala2 is drawn. S. agalactiae can have Ser-containing bridges; S. mutans can have Ala2–3. Hydrolases are species-specific; PlyPy is a phage enzyme."]},"es":{"title":"Estreptococos · puentes Ala","synth":"Ensamblaje de ramas tipo Mur/Fem y sistemas PBP/SEDS; verificar homólogos por especie.","notes":["Se dibuja Ala2. S. agalactiae puede contener Ser y S. mutans Ala2–3. Las hidrolasas son específicas de especie; PlyPy es una enzima fágica."]}},"chemotype":"A3α","chemotypeReview":{"kind":"existing_plate","plateSlug":"strepto","chemotype":"A3α","dsmzCode":"A11.5","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A3α classifies the displayed Ala2 structure. The combined species heading is not evidence that all listed organisms share it.","zh":"A3α 是所画 Ala2 结构的分型；合并菌种标题不证明所有所列菌都具有该结构。","es":"A3α clasifica la estructura Ala2 mostrada; el encabezado multiespecie no demuestra que todas la compartan."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A11.5","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A11.5","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"L-Lys","bridgeFromAcceptor":["L-Ala","L-Ala"],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","groupingWarning":"The combined taxon heading is not a claim of uniform native structure.","sourceIds":["REF0198","REF0200"]}},{"slug":"lys_direct","title":"直接交联的 Lys 型 · S. suis 31533","latin":"S. suis","x":"L-Lys","bridge":[],"cross":"43","enzspecies":["S. suis / S. oralis"],"synth":"PBP型D,D-transpeptidation；无额外桥肽","notes":["Lys型不一定有额外交联桥。\n此页给化学结构定位；没有独立核实的种特异酶不从肺炎链球菌移植。\n肺炎链球菌的无桥亚群也可参照此结构，仍需其本身的酶证据。\nS. suis 31533 来源为 Cellosyl/HPLC/MS，含 D-iGln 肽干。不可对全部 S. oralis 声称直接 Lys 交联：Uo5 有 L-Ala 桥。"],"refs":["R26","R131","R133"],"gln":true,"modified":"","unknown":false,"i18n":{"en":{"title":"Direct Lys crosslinks · S. suis 31533","synth":"PBP-mediated D,D-transpeptidation without an additional peptide bridge.","notes":["Lys-type PG need not contain a bridge. This is structural coverage, not a transferred hydrolase inventory. Unbranched pneumococcal stems share this chemical framework.\nS. suis 31533 source: Cellosyl/HPLC/MS, D-iGln-containing stems. S. oralis is excluded from a species-wide direct-Lys claim: Uo5 has an L-Ala bridge."]},"es":{"title":"Entrecruzamientos Lys directos · S. suis 31533","synth":"Transpeptidación D,D mediada por PBP sin puente peptídico adicional.","notes":["El PG tipo Lys no requiere puente. La cobertura es estructural, no un catálogo de hidrolasas transferido. Los tallos neumocócicos sin rama comparten este esquema.\nS. suis 31533: Cellosyl/HPLC/MS, tallos con D-iGln. No se extiende el modelo Lys directo a toda S. oralis: Uo5 tiene puente L-Ala."]}},"chemotype":"A1α","chemotypeReview":{"kind":"existing_plate","plateSlug":"lys_direct","chemotype":"A1α","dsmzCode":"A11","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1α describes the displayed direct Lys linkage. Do not transfer this model to S. oralis or all S. suis strains.","zh":"A1α 描述所画 Lys 直接交联；不可外推至 S. oralis 或所有 S. suis 菌株。","es":"A1α describe el enlace directo de Lys mostrado; no debe trasladarse a S. oralis ni a todas las cepas de S. suis."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A11","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A11","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"L-Lys","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}},{"slug":"lactis","title":"乳酸乳球菌","latin":"L. lactis","x":"L-Lys","bridge":["D-iAsx"],"cross":"43","enzspecies":["L. lactis"],"synth":"AslA：D-Asp连接；AsnH：桥酰胺化；PBP/SEDS聚合和交联","notes":["AcmA和AcmB均切G；不能因为与胞壁质酶相似就改标M。\n第二位和桥的酰胺化状态需按样品确认。"],"refs":["R29","R30","R31","REF0157"],"gln":true,"modified":"","unknown":false,"i18n":{"en":{"title":"Lactococcus lactis","synth":"AslA attaches D-Asp; AsnH amidates the bridge; PBP/SEDS polymerize and crosslink PG.","notes":["AcmA and AcmB cleave G, not M. Amidation of residue 2 and the bridge must be checked for each sample."]},"es":{"title":"Lactococcus lactis","synth":"AslA incorpora D-Asp; AsnH amida el puente; PBP/SEDS polimerizan y entrecruzan PG.","notes":["AcmA y AcmB cortan G, no M. Verificar en cada muestra la amidación del residuo 2 y del puente."]}},"chemotype":"A4α","chemotypeReview":{"kind":"existing_plate","plateSlug":"lactis","chemotype":"A4α","dsmzCode":"A11.31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A4α applies at bridge-family level; DSM 20175 is an A11.31 example. Amidation remains source-specific.","zh":"A4α 适用于桥家族层面；DSM 20175 是 A11.31 实例。酰胺化状态须按来源区分。","es":"A4α se aplica a la familia del puente; DSM 20175 es un ejemplo de A11.31. La amidación depende de la fuente."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A11.31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A11.31","access":"full_text","role":"official_nomenclature"},{"id":"DSM20175","url":"https://www.dsmz.de/collection/catalogue/details/culture/DSM-20175","locator":"Strain summary, Murein A11.31","access":"indexed_excerpt","role":"official_strain_example"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"L-Lys","bridgeFromAcceptor":["D-iAsx"],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","dsmzCodeScope":"A11.31 is the D-Asp representative. The displayed Asx shorthand does not independently resolve Asp/Asn or amidation.","sourceIds":["REF0198","REF0201","REF0200"]}},{"slug":"plantarum","title":"植物乳植杆菌","latin":"L. plantarum","x":"mDAP","bridge":[],"cross":"43","enzspecies":["L. plantarum"],"synth":"MurE引入mDAP；SEDS/PBP系统；某些前体以D-Ala-D-Lac结尾","notes":["成熟PG的常见肽干与前体D-Ala-D-Lac末端需区分。\nAcm2切G；LytA/LytB切23。\nD-Glu与mDAP可酰胺化；图的mDAP节点包含这一变体。"],"refs":["R32","R33","R56","R73"],"gln":true,"modified":"","unknown":false,"i18n":{"en":{"title":"Lactiplantibacillus plantarum","synth":"MurE introduces mDAP; SEDS/PBP synthesis; some precursors terminate in D-Ala–D-Lac.","notes":["Distinguish mature stems from D-Ala–D-Lac precursors. Acm2 cleaves G and LytA/B cleave 23. D-Glu and mDAP may be amidated."]},"es":{"title":"Lactiplantibacillus plantarum","synth":"MurE incorpora mDAP; síntesis SEDS/PBP; algunos precursores terminan en D-Ala–D-Lac.","notes":["Distinguir tallos maduros y precursores D-Ala–D-Lac. Acm2 corta G y LytA/B cortan 23. D-Glu y mDAP pueden estar amidados."]}},"chemotype":"A1γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"plantarum","chemotype":"A1γ","dsmzCode":"A31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1γ labels the displayed 4→3 direct meso-DAP topology; it does not certify every native unit or glycan modification.","zh":"A1γ 标记所画 meso-DAP 直接 4→3 拓扑，不等于已核实每个原生单元或糖链修饰。","es":"A1γ identifica la topología directa meso-DAP 4→3 mostrada; no certifica cada unidad nativa ni sus modificaciones."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}},{"slug":"bacillus","title":"枯草芽孢杆菌：营养细胞","latin":"B. subtilis","x":"mDAP","bridge":[],"cross":"43","enzspecies":["B. subtilis"],"synth":"RodA-PBP2A/PbpH；FtsW-PBP2B；aPBP系统","notes":["LytE/CwlO切的是肽干23键，不是直接切43交联键。\nmDAP常有酰胺化；芽孢皮层与此处营养细胞底物不同。"],"refs":["R34","R64"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Bacillus subtilis · vegetative","synth":"RodA–PBP2A/PbpH, FtsW–PBP2B and aPBP systems.","notes":["LytE/CwlO cleave stem bond 23, not crosslink 43. mDAP is often amidated. Spore cortex is a separate substrate context."]},"es":{"title":"Bacillus subtilis · vegetativo","synth":"Sistemas RodA–PBP2A/PbpH, FtsW–PBP2B y aPBP.","notes":["LytE/CwlO cortan el enlace 23 del tallo, no el entrecruzamiento 43. mDAP suele estar amidado. La corteza de espora es otro contexto de sustrato."]}},"chemotype":"A1γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"bacillus","chemotype":"A1γ","dsmzCode":"A31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1γ labels the displayed 4→3 direct meso-DAP topology; it does not certify every native unit or glycan modification.","zh":"A1γ 标记所画 meso-DAP 直接 4→3 拓扑，不等于已核实每个原生单元或糖链修饰。","es":"A1γ identifica la topología directa meso-DAP 4→3 mostrada; no certifica cada unidad nativa ni sus modificaciones."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}},{"slug":"listeria","title":"单核细胞增生李斯特菌","latin":"L. monocytogenes","x":"mDAP","bridge":[],"cross":"43","enzspecies":["L. monocytogenes"],"synth":"Mur前体通路；PBP/SEDS系统；AsnB参与DAP酰胺化","notes":["p60/Iap标23；Ami标A；Auto标G。\nNamA/MurA在不同来源中的糖苷酶命名不一致：本版不强行判定键。\nPG可脱乙酰化；键的存在不等于各酶的活性强度相同。"],"refs":["R35","REF0194","REF0195"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Listeria monocytogenes","synth":"Mur precursor pathway, PBP/SEDS systems and AsnB-dependent DAP amidation.","notes":["p60/Iap: 23; Ami: A; Auto: G. Sources disagree on NamA/MurA glycosidase naming. PG deacetylation and substrate accessibility affect activity."]},"es":{"title":"Listeria monocytogenes","synth":"Ruta de precursores Mur, sistemas PBP/SEDS y amidación de DAP dependiente de AsnB.","notes":["p60/Iap: 23; Ami: A; Auto: G. Las fuentes discrepan en la denominación glucosidasa de NamA/MurA. La desacetilación y accesibilidad afectan la actividad."]}},"chemotype":"A1γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"listeria","chemotype":"A1γ","dsmzCode":"A31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1γ labels the displayed 4→3 direct meso-DAP topology; it does not certify every native unit or glycan modification.","zh":"A1γ 标记所画 meso-DAP 直接 4→3 拓扑，不等于已核实每个原生单元或糖链修饰。","es":"A1γ identifica la topología directa meso-DAP 4→3 mostrada; no certifica cada unidad nativa ni sus modificaciones."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}},{"slug":"cdiff","title":"艰难梭菌：主要3→3型","latin":"C. difficile","x":"mDAP","bridge":[],"cross":"33","enzspecies":["C. difficile"],"synth":"L,D-转肽作用贡献显著；不能将所有3→3交联完全归给单一Ldt","notes":["还存在4→3交联和更复杂连接；此页只画主要经典3→3框架。\n糖链常高度GlcNAc脱乙酰化；不是每个糖都固定同一状态。\nCwlA切23，Cwp19为产生anhydro端的LT。"],"refs":["R37","R38","R39","R40"],"gln":false,"modified":"GlcN-rich","unknown":false,"i18n":{"en":{"title":"Clostridioides difficile · 3–3","synth":"L,D-transpeptidation contributes strongly; do not assign all 3–3 links to a single Ldt.","notes":["4–3 and more complex links also occur. GlcNAc is often extensively deacetylated. CwlA cleaves 23; Cwp19 is an LT producing anhydro ends."]},"es":{"title":"Clostridioides difficile · 3–3","synth":"La transpeptidación L,D contribuye de forma importante; no atribuir todos los enlaces 3–3 a una sola Ldt.","notes":["También existen enlaces 4–3 y más complejos. GlcNAc suele estar muy desacetilada. CwlA corta 23; Cwp19 es una LT que produce extremos anhidro."]}},"chemotype":null,"chemotypeReview":{"kind":"existing_plate","plateSlug":"cdiff","chemotype":null,"dsmzCode":null,"checked":"2026-11-07","reviewStatus":"outside_displayed_classic_scheme","scope":{"en":"The displayed 3→3 linkage only; retain a separate topology label.","zh":"仅针对所画 3→3 连接；保留独立拓扑标签。","es":"Solo el enlace 3→3 mostrado; conservar una etiqueta de topología separada."},"note":{"en":"Keep the displayed 3→3 topology separately annotated. No classical 4→3 chemotype code is assigned to this linkage.","zh":"所画 3→3 拓扑单独标注；不把经典 4→3 分型号套在此连接上。","es":"Mantener la topología 3→3 mostrada como anotación separada; no asignarle un código clásico de enlace 4→3."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A classification boundaries; displayed 3→3 topology left unclassified","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A classification boundaries; displayed 3→3 topology left unclassified","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"3→3"},"diagramAction":"label_only_do_not_change_bonds","classicalContext":{"chemotype":"A1γ","appliesTo":"Corresponding 4→3 structural subgroup only, if independently documented; not this 3→3 diagram."},"sourceIds":["REF0198","REF0200"]}},{"slug":"ecoli","title":"大肠杆菌：主要4→3型","latin":"E. coli","x":"mDAP","bridge":[],"cross":"43","enzspecies":["E. coli"],"synth":"RodA-PBP2伸长；FtsW-PBP3/FtsI分裂；PBP1A/1B辅助聚合交联","notes":["Mep类中多种酶可切43和33；不能只按D,D/L,D名称推断底物谱。\n45示意受体五肽末端；34羧肽酶需要四肽底物，见修剪图。\n回收酶另页说明；不能全部当成完整胞壁的周质自溶素。"],"refs":["R46","R47","R64","R65","R76"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Escherichia coli · 4–3","synth":"RodA–PBP2 elongation; FtsW–PBP3/FtsI division; PBP1A/1B also polymerize and crosslink.","notes":["Several Mep enzymes cleave both 43 and 33. Carboxypeptidase 45 requires a pentapeptide, and 34 a tetrapeptide. Recycling enzymes have a separate substrate context."]},"es":{"title":"Escherichia coli · 4–3","synth":"Elongación RodA–PBP2; división FtsW–PBP3/FtsI; PBP1A/1B también polimerizan y entrecruzan.","notes":["Varias enzimas Mep cortan 43 y 33. La carboxipeptidasa 45 requiere un pentapéptido y la 34 un tetrapéptido. Las enzimas de reciclaje tienen otro contexto."]}},"chemotype":"A1γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"ecoli","chemotype":"A1γ","dsmzCode":"A31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1γ labels the displayed 4→3 direct meso-DAP topology; it does not certify every native unit or glycan modification.","zh":"A1γ 标记所画 meso-DAP 直接 4→3 拓扑，不等于已核实每个原生单元或糖链修饰。","es":"A1γ identifica la topología directa meso-DAP 4→3 mostrada; no certifica cada unidad nativa ni sus modificaciones."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}},{"slug":"ecoli_ld","title":"大肠杆菌：3→3亚群","latin":"E. coli","x":"mDAP","bridge":[],"cross":"33","enzspecies":["E. coli"],"synth":"Ldt类酶产生mDAP3-mDAP3交联；比例随菌株/状态变化","notes":["MepK偏好33；MepM/MepS/MepH/MepA也有33切割证据，活性不完全相同。\n3→3供体不能再保留第4/5位；34修剪只对相应四肽底物解释。"],"refs":["R47","R76"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Escherichia coli · 3–3 subset","synth":"Ldt enzymes form mDAP3–mDAP3 links; abundance depends on strain and state.","notes":["MepK prefers 33; MepM/S/H/A also have 33 activity with different preferences. Mature 3–3 donors lack residues 4 and 5."]},"es":{"title":"Escherichia coli · fracción 3–3","synth":"Las Ldt forman enlaces mDAP3–mDAP3; su abundancia depende de cepa y estado.","notes":["MepK prefiere 33; MepM/S/H/A también tienen actividad 33 con distintas preferencias. Los donantes maduros 3–3 carecen de residuos 4 y 5."]}},"chemotype":null,"chemotypeReview":{"kind":"existing_plate","plateSlug":"ecoli_ld","chemotype":null,"dsmzCode":null,"checked":"2026-11-07","reviewStatus":"outside_displayed_classic_scheme","scope":{"en":"The displayed 3→3 linkage only; retain a separate topology label.","zh":"仅针对所画 3→3 连接；保留独立拓扑标签。","es":"Solo el enlace 3→3 mostrado; conservar una etiqueta de topología separada."},"note":{"en":"Keep the displayed 3→3 topology separately annotated. No classical 4→3 chemotype code is assigned to this linkage.","zh":"所画 3→3 拓扑单独标注；不把经典 4→3 分型号套在此连接上。","es":"Mantener la topología 3→3 mostrada como anotación separada; no asignarle un código clásico de enlace 4→3."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A classification boundaries; displayed 3→3 topology left unclassified","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A classification boundaries; displayed 3→3 topology left unclassified","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"3→3"},"diagramAction":"label_only_do_not_change_bonds","classicalContext":{"chemotype":"A1γ","appliesTo":"Corresponding 4→3 structural subgroup only, if independently documented; not this 3→3 diagram."},"sourceIds":["REF0198","REF0200"]}},{"slug":"pseudomonas","title":"铜绿假单胞菌","latin":"P. aeruginosa","x":"mDAP","bridge":[],"cross":"43","enzspecies":["P. aeruginosa"],"synth":"SEDS-bPBP与aPBP系统；D,D交联为主要框架","notes":["MepM等参与交联重塑；PA编号不能跨菌株直接当作通用基因名。\nLbcA/CtpA调控蛋白水解，不是图中直接切PG的酶。"],"refs":["R48"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Pseudomonas aeruginosa","synth":"SEDS–bPBP and aPBP systems; the diagram shows D,D crosslinks.","notes":["MepM participates in remodelling. PA locus identifiers are not universal across strains. LbcA/CtpA regulate proteolysis rather than directly cutting PG."]},"es":{"title":"Pseudomonas aeruginosa","synth":"Sistemas SEDS–bPBP y aPBP; el dibujo muestra enlaces D,D.","notes":["MepM participa en la remodelación. Los identificadores PA no son universales entre cepas. LbcA/CtpA regulan proteólisis, no cortan PG directamente."]}},"chemotype":"A1γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"pseudomonas","chemotype":"A1γ","dsmzCode":"A31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1γ labels the displayed 4→3 direct meso-DAP topology; it does not certify every native unit or glycan modification.","zh":"A1γ 标记所画 meso-DAP 直接 4→3 拓扑，不等于已核实每个原生单元或糖链修饰。","es":"A1γ identifica la topología directa meso-DAP 4→3 mostrada; no certifica cada unidad nativa ni sus modificaciones."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}},{"slug":"acinetobacter","title":"鲍曼不动杆菌","latin":"A. baumannii","x":"mDAP","bridge":[],"cross":"43","enzspecies":["A. baumannii"],"synth":"PBP/SEDS系统；LdtJ等L,D途径需与回收酶ElsL分开","notes":["ElsL是胞内L,D-羧肽酶，不是交联酶。\nPBP7有D,D肽酶活性；其编号不代表与别的菌同一功能。"],"refs":["R49","R50"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Acinetobacter baumannii","synth":"PBP/SEDS systems; distinguish LdtJ-related L,D pathways from ElsL recycling.","notes":["ElsL is a cytoplasmic L,D-carboxypeptidase, not a crosslinking enzyme. PBP7 has D,D-peptidase activity; PBP numbering is species-specific."]},"es":{"title":"Acinetobacter baumannii","synth":"Sistemas PBP/SEDS; distinguir rutas L,D relacionadas con LdtJ del reciclaje por ElsL.","notes":["ElsL es una L,D-carboxipeptidasa citoplasmática, no una enzima de entrecruzamiento. PBP7 tiene actividad D,D-peptidasa; la numeración PBP depende de la especie."]}},"chemotype":"A1γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"acinetobacter","chemotype":"A1γ","dsmzCode":"A31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1γ labels the displayed 4→3 direct meso-DAP topology; it does not certify every native unit or glycan modification.","zh":"A1γ 标记所画 meso-DAP 直接 4→3 拓扑，不等于已核实每个原生单元或糖链修饰。","es":"A1γ identifica la topología directa meso-DAP 4→3 mostrada; no certifica cada unidad nativa ni sus modificaciones."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}},{"slug":"vibrio","title":"霍乱弧菌","latin":"V. cholerae","x":"mDAP","bridge":[],"cross":"43","enzspecies":["V. cholerae"],"synth":"PBP/SEDS系统；示意主要D,D交联","notes":["ShyA在交联43键作用；ShyB/ShyC的条件依赖不由本图表示。\n非典型D-氨基酸可替换肽干末端；这不是新建一种固定桥。"],"refs":["R51"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Vibrio cholerae","synth":"PBP/SEDS systems; representative D,D crosslink.","notes":["ShyA cleaves 43; ShyB/C depend on biological context. Noncanonical D-amino acids can replace terminal residues without creating a fixed new bridge."]},"es":{"title":"Vibrio cholerae","synth":"Sistemas PBP/SEDS; entrecruzamiento D,D representativo.","notes":["ShyA corta 43; ShyB/C dependen del contexto. Aminoácidos D no canónicos pueden sustituir residuos terminales sin crear un puente fijo nuevo."]}},"chemotype":"A1γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"vibrio","chemotype":"A1γ","dsmzCode":"A31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1γ labels the displayed 4→3 direct meso-DAP topology; it does not certify every native unit or glycan modification.","zh":"A1γ 标记所画 meso-DAP 直接 4→3 拓扑，不等于已核实每个原生单元或糖链修饰。","es":"A1γ identifica la topología directa meso-DAP 4→3 mostrada; no certifica cada unidad nativa ni sus modificaciones."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}},{"slug":"neisseria","title":"奈瑟菌","latin":"Neisseria spp.","x":"mDAP","bridge":[],"cross":"43","enzspecies":["Neisseria spp.","N. gonorrhoeae"],"synth":"PBP系统；淋病奈瑟菌和脑膜炎奈瑟菌的重塑依赖并不完全相同","notes":["AmiC切A；LtgA/LtgD为LT；LdcA的回收/周质底物需按物种看。\nDacB/PBP3属于肽酶条目，不要套用E. coli PBP3/FtsI的功能。"],"refs":["R52"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Neisseria","synth":"PBP systems; remodelling requirements differ between gonococcus and meningococcus.","notes":["AmiC: A; LtgA/D: LT. LdcA substrates and localization require species context. DacB/PBP3 is not equivalent to E. coli PBP3/FtsI."]},"es":{"title":"Neisseria","synth":"Sistemas PBP; la remodelación difiere entre gonococo y meningococo.","notes":["AmiC: A; LtgA/D: LT. Los sustratos y localización de LdcA requieren contexto de especie. DacB/PBP3 no equivale a PBP3/FtsI de E. coli."]}},"chemotype":"A1γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"neisseria","chemotype":"A1γ","dsmzCode":"A31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1γ labels the displayed 4→3 direct meso-DAP topology; it does not certify every native unit or glycan modification.","zh":"A1γ 标记所画 meso-DAP 直接 4→3 拓扑，不等于已核实每个原生单元或糖链修饰。","es":"A1γ identifica la topología directa meso-DAP 4→3 mostrada; no certifica cada unidad nativa ni sus modificaciones."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","groupingWarning":"The combined taxon heading is not a claim of uniform native structure.","sourceIds":["REF0198","REF0200"]}},{"slug":"helical","title":"螺旋/弯曲杆菌的肽干修剪","latin":"H. pylori / C. jejuni","x":"mDAP","bridge":[],"cross":"43","enzspecies":["H. pylori","C. jejuni"],"synth":"PBP/SEDS合成与肽干修剪共同影响PG结构","notes":["Pgp2/Csd6：四肽→三肽；Pgp1/Csd4：三肽→二肽。\n同一23键作为末端切割或内部切割时，酶学名称不同。\nCsd2/Csd5/CcmA不能仅因影响形态就当作已验证PG切割酶。"],"refs":["R53","R54","R55"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Helicobacter / Campylobacter","synth":"PBP/SEDS synthesis and stem trimming jointly shape PG architecture.","notes":["Pgp2/Csd6: tetra to tri; Pgp1/Csd4: tri to di. Bond 23 can be terminal or internal in different substrates. Shape effects alone do not establish Csd2/Csd5/CcmA as hydrolases."]},"es":{"title":"Helicobacter / Campylobacter","synth":"La síntesis PBP/SEDS y el recorte de tallos determinan conjuntamente la arquitectura del PG.","notes":["Pgp2/Csd6: tetra a tri; Pgp1/Csd4: tri a di. El enlace 23 puede ser terminal o interno según el sustrato. El efecto morfológico no demuestra que Csd2/Csd5/CcmA sean hidrolasas."]}},"chemotype":"A1γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"helical","chemotype":"A1γ","dsmzCode":"A31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1γ labels the displayed 4→3 direct meso-DAP topology; it does not certify every native unit or glycan modification.","zh":"A1γ 标记所画 meso-DAP 直接 4→3 拓扑，不等于已核实每个原生单元或糖链修饰。","es":"A1γ identifica la topología directa meso-DAP 4→3 mostrada; no certifica cada unidad nativa ni sus modificaciones."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","groupingWarning":"The combined taxon heading is not a claim of uniform native structure.","sourceIds":["REF0198","REF0200"]}},{"slug":"mycobacterium","title":"分枝杆菌：3→3与特殊修饰","latin":"M. tuberculosis","x":"mDAP","bridge":[],"cross":"33","enzspecies":["M. tuberculosis"],"synth":"PBP产生4→3；Ldt产生3→3；NamH参与MurNAc N-glycolyl化","notes":["图示3→3；实际还存在4→3，比例不是跨生长条件的常数。\nRipA/B切23；Ami1切A；Rpf家族不在本版统一确定产物类别。\nCwlM是调控因子，不能因酰胺酶样结构域就画A切点。"],"refs":["R43","R45","REF0192","REF0193"],"gln":true,"modified":"MurNGly / MurNAc","unknown":false,"i18n":{"en":{"title":"Mycobacterium · 3–3","synth":"PBPs form 4–3 links; Ldts form 3–3; NamH participates in MurNAc N-glycolylation.","notes":["Both link classes occur, with variable proportions. RipA/B: 23; Ami1: A. Rpf family products are not assigned collectively. CwlM is a regulator, not an A-site enzyme."]},"es":{"title":"Mycobacterium · 3–3","synth":"Las PBP forman 4–3; las Ldt, 3–3; NamH participa en la N-glicolilación de MurNAc.","notes":["Existen ambos enlaces en proporciones variables. RipA/B: 23; Ami1: A. No se asignan productos a toda la familia Rpf. CwlM es regulador, no enzima del sitio A."]}},"chemotype":null,"chemotypeReview":{"kind":"existing_plate","plateSlug":"mycobacterium","chemotype":null,"dsmzCode":null,"checked":"2026-11-07","reviewStatus":"outside_displayed_classic_scheme","scope":{"en":"The displayed 3→3 linkage only; retain a separate topology label.","zh":"仅针对所画 3→3 连接；保留独立拓扑标签。","es":"Solo el enlace 3→3 mostrado; conservar una etiqueta de topología separada."},"note":{"en":"Keep the displayed 3→3 topology separately annotated. No classical 4→3 chemotype code is assigned to this linkage.","zh":"所画 3→3 拓扑单独标注；不把经典 4→3 分型号套在此连接上。","es":"Mantener la topología 3→3 mostrada como anotación separada; no asignarle un código clásico de enlace 4→3."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A classification boundaries; displayed 3→3 topology left unclassified","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A classification boundaries; displayed 3→3 topology left unclassified","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"3→3"},"diagramAction":"label_only_do_not_change_bonds","classicalContext":{"chemotype":"A1γ","appliesTo":"Corresponding 4→3 structural subgroup only, if independently documented; not this 3→3 diagram."},"sourceIds":["REF0198","REF0200"]}},{"slug":"corynebacterium","title":"谷氨酸棒杆菌：酰胺化mDAP型","latin":"C. glutamicum","x":"mDAP","bridge":[],"cross":"43","enzspecies":["C. glutamicum"],"synth":"LtsA：DAP酰胺化；PBP及L,D转肽途径参与PG装配","notes":["图示直接4→3结构；不能将分枝杆菌的3→3比例或糖修饰直接套用。\nD-Glu和mDAP均可酰胺化；程度需按菌株和样品解释。\n本版核实结构与LtsA修饰；未将预测水解酶当作确定切点。"],"refs":["R42"],"gln":true,"modified":"amidated mDAP","unknown":false,"i18n":{"en":{"title":"Corynebacterium · amidated mDAP","synth":"LtsA amidates DAP; PBP and L,D-transpeptidation pathways assemble PG.","notes":["Direct 4–3 structure is shown. Do not transfer mycobacterial crosslink proportions or sugar modifications. D-Glu/mDAP amidation varies; candidate hydrolases are not assigned definite bonds."]},"es":{"title":"Corynebacterium · mDAP amidado","synth":"LtsA amida DAP; rutas PBP y de transpeptidación L,D ensamblan PG.","notes":["Se muestra 4–3 directo. No transferir proporciones ni modificaciones de micobacterias. La amidación varía; no se asignan enlaces definitivos a hidrolasas candidatas."]}},"chemotype":"A1γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"corynebacterium","chemotype":"A1γ","dsmzCode":"A31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1γ labels the displayed 4→3 direct meso-DAP topology; it does not certify every native unit or glycan modification.","zh":"A1γ 标记所画 meso-DAP 直接 4→3 拓扑，不等于已核实每个原生单元或糖链修饰。","es":"A1γ identifica la topología directa meso-DAP 4→3 mostrada; no certifica cada unidad nativa ni sus modificaciones."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}},{"slug":"lldap","title":"LL-DAP + Gly桥型","latin":"C. perfringens / Streptomyces spp.","x":"LL-DAP","bridge":["Gly"],"cross":"43","enzspecies":["C. perfringens / Streptomyces spp."],"synth":"MurE选择LL-DAP；Gly支链与PBP交联共同构建此化学型","notes":["此页直接展示典型结构，不从B. subtilis的mDAP型复制酶名。\nLL-DAP与meso-DAP不是同一个立体异构体。\n不同Streptomyces可能有不同交联亚群；图示经典4→3框架。"],"refs":["R41"],"gln":true,"modified":"","unknown":false,"i18n":{"en":{"title":"LL-DAP + Gly bridge","synth":"MurE selects LL-DAP; Gly branches and PBP crosslinking build this chemotype.","notes":["LL-DAP and meso-DAP are stereoisomers. This is a classical 4–3 framework; Streptomyces crosslink subsets vary. B. subtilis enzyme names are not transferred."]},"es":{"title":"LL-DAP + puente Gly","synth":"MurE selecciona LL-DAP; ramas Gly y entrecruzamiento por PBP construyen este quimiotipo.","notes":["LL-DAP y meso-DAP son estereoisómeros. Es un esquema 4–3 clásico; las fracciones de Streptomyces varían. No se transfieren enzimas de B. subtilis."]}},"chemotype":"A3γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"lldap","chemotype":"A3γ","dsmzCode":"A41.1","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A3γ classifies the displayed LL-DAP/Gly subgroup. The genus Streptomyces and C. perfringens are not interchangeable evidence.","zh":"A3γ 对应所画 LL-DAP/Gly 亚型；Streptomyces 属与 C. perfringens 的证据不可互相替代。","es":"A3γ clasifica el subgrupo LL-DAP/Gly mostrado; Streptomyces y C. perfringens no son evidencia intercambiable."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A41.1","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A41.1","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"LL-DAP","bridgeFromAcceptor":["Gly"],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","groupingWarning":"The combined taxon heading is not a claim of uniform native structure.","sourceIds":["REF0198","REF0200"]}},{"slug":"bifido","title":"双歧杆菌：以青春双歧杆菌为例","latin":"B. adolescentis","x":"L-Lys","bridge":["D-iAsx"],"cross":"43","enzspecies":["B. adolescentis","Bifidobacterium spp."],"synth":"MurE底物选择及支链装配因物种而异；Asl/AsnH同源证据需另分级","notes":["本图只表示Lys-D-Asx亚群；同一样品可同时有Orn型。\nB. bifidum与B. infantis中Orn型占优，不能直接替换名称复用本图。\nMltG/RpfB研究含体外替代底物；不推断全部体内作用。"],"refs":["R56","R57"],"gln":true,"modified":"","unknown":false,"i18n":{"en":{"title":"Bifidobacterium adolescentis","synth":"MurE specificity and branch assembly vary by species; Asl/AsnH homology requires separate evidence.","notes":["Only the Lys–D-Asx subset is drawn; Orn stems may coexist. B. bifidum/infantis are Orn-rich and cannot be represented by renaming this graph. MltG/RpfB evidence includes in vitro heterologous substrates."]},"es":{"title":"Bifidobacterium adolescentis","synth":"La especificidad de MurE y las ramas varían por especie; la homología Asl/AsnH requiere evidencia aparte.","notes":["Solo se dibuja la fracción Lys–D-Asx; pueden coexistir tallos Orn. B. bifidum/infantis, ricos en Orn, no se representan renombrando este gráfico. MltG/RpfB incluye sustratos heterólogos in vitro."]}},"chemotype":"A4α","chemotypeReview":{"kind":"existing_plate","plateSlug":"bifido","chemotype":"A4α","dsmzCode":"A11.31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A4α applies only to the displayed Lys-containing subgroup; it cannot classify Orn-containing variants.","zh":"A4α 仅适用于所画含 Lys 亚型，不能替代含 Orn 变体的分型。","es":"A4α se aplica solo al subgrupo mostrado con Lys, no a variantes con Orn."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A11.31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A11.31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"L-Lys","bridgeFromAcceptor":["D-iAsx"],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","dsmzCodeScope":"A11.31 is the D-Asp representative. The displayed Asx shorthand does not independently resolve Asp/Asn or amidation.","sourceIds":["REF0198","REF0200"]}},{"slug":"fusobacterium","title":"具核梭杆菌：lanthionine型","latin":"F. nucleatum","x":"Lan","bridge":[],"cross":"43","enzspecies":["F. nucleatum"],"synth":"前体第3位为lanthionine；保留通用Mur/PBP框架但不能套用DAP","notes":["Lan = lanthionine，不是Leu，也不是L-Ala。\n本版核实的是结构；未将未验证的同源水解酶强行标到键上。"],"refs":["R56","R58"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Fusobacterium · lanthionine","synth":"Residue 3 is lanthionine; retain the Mur/PBP framework without substituting DAP.","notes":["Lan means lanthionine, not Leu or L-Ala. Structural evidence is included; unverified hydrolase homologues have no assigned sites."]},"es":{"title":"Fusobacterium · lantionina","synth":"El residuo 3 es lantionina; conservar el esquema Mur/PBP sin sustituirlo por DAP.","notes":["Lan significa lantionina, no Leu ni L-Ala. Se incluye evidencia estructural; no se asignan sitios a homólogos de hidrolasas sin verificar."]}},"chemotype":"A1δ","chemotypeReview":{"kind":"existing_plate","plateSlug":"fusobacterium","chemotype":"A1δ","dsmzCode":"A51","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"Lan-direct is A1δ, proposed in 1982 and retained by DSMZ. A1γ′ instead denotes a meso-DAP type with Gly at stem position 1.","zh":"Lan 直接型为 A1δ，1982 年原文提出且 DSMZ 沿用。A1γ′ 是主肽第 1 位为 Gly 的 meso-DAP 型。","es":"Lan directo es A1δ, propuesto en 1982 y conservado por DSMZ. A1γ′ es un tipo meso-DAP con Gly en la posición 1 del tallo."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A51; compare row A32.1 and endnote a","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A51; compare row A32.1 and endnote a","access":"full_text","role":"official_nomenclature"},{"id":"VASSTRAND1982","title":"Composition of peptidoglycans in Bacteroidaceae: determination and distribution of lanthionine","url":"https://pubmed.ncbi.nlm.nih.gov/7076290/","doi":"10.1128/IAI.36.1.114-122.1982","year":1982,"locator":"Abstract: proposal of the A1 delta chemotype for lanthionine-containing Fusobacterium peptidoglycans","access":"abstract","role":"original_chemotype_proposal"},{"id":"DSM20482","url":"https://www.dsmz.de/collection/catalogue/details/culture/dsm-20482","locator":"Fusobacterium nucleatum subsp. polymorphum, strain 555A; Murein A51","access":"full_text","role":"official_strain_example"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"Lan","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","classificationHistory":{"proposedYear":1982,"proposedCode":"A1δ","claim":"This is a later extension; do not imply it was introduced in the 1972 paper."},"rejectedLabel":{"label":"A1γ′","reason":"DSMZ A32.1 is meso-DAP-direct with Gly replacing L-Ala at stem position 1; it is not the lanthionine class."},"sourceIds":["REF0198","REF0202","REF0203","REF0200"]}},{"slug":"borrelia","title":"伯氏疏螺旋体：Orn + Gly型","latin":"B. burgdorferi","x":"L-Orn","bridge":["Gly"],"cross":"43","enzspecies":["B. burgdorferi"],"synth":"L-Orn为第3位；Gly侧链/桥；PBP介导装配","notes":["有特殊糖链修饰；图只显示PG基本连接框架。\n预印本 R61 报告 MltS 生成 1,6-脱水胞壁酸产物；与宿主胞壁质酶反应不同。"],"refs":["R60","R61"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Borrelia · Orn + Gly","synth":"L-Orn at position 3, with a Gly branch/bridge and PBP-mediated assembly.","notes":["Additional glycan modifications are not drawn. Preprint R61 reports MltS-generated anhydro products, distinct from host muramidase chemistry."]},"es":{"title":"Borrelia · Orn + Gly","synth":"L-Orn en posición 3, con rama/puente Gly y ensamblaje mediado por PBP.","notes":["No se dibujan modificaciones adicionales del glicano. MltS corta M y forma productos anhidro; su química difiere de la muramidasa del huésped. (R61: preprint.)"]}},"chemotype":"A3β","chemotypeReview":{"kind":"existing_plate","plateSlug":"borrelia","chemotype":"A3β","dsmzCode":null,"checked":"2026-11-07","reviewStatus":"class_mapping_with_primary_structural_support","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"The displayed Orn/Gly bridge fits A3β at class level. Do not assign DSMZ A21.1: that row specifies Gly2–3, not this single-Gly example.","zh":"所画 Orn/Gly 桥在类别层面对应 A3β。不要套用 DSMZ A21.1：该行指定 Gly2–3，而此处为单 Gly。","es":"El puente Orn/Gly mostrado corresponde a A3β a nivel de clase. No asignar A21.1: esa fila especifica Gly2–3, no este ejemplo de una Gly."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, A3β family; A21.1 is a different bridge-length example","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, A3β family; A21.1 is a different bridge-length example","access":"full_text","role":"official_nomenclature"},{"id":"JUTRAS2019","title":"Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6613144/","doi":"10.1073/pnas.1904170116","year":2019,"locator":"Figure 1A and associated structural description; SI Appendix Table S1","access":"indexed_excerpt","role":"species_specific_Orn_single_Gly_structure"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"A3β is a class-level inference from the official nomenclature plus the source's Orn/single-Gly structure; no exact DSMZ row code is asserted.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"L-Orn","bridgeFromAcceptor":["Gly"],"crosslink":"4→3"},"diagramAction":"label_only_preserve_single_Gly_do_not_expand_to_Gly2_or_Gly3","sourceIds":["REF0198","REF0060","REF0200"]}},{"slug":"chlamydia","title":"衣原体：分裂局部PG","latin":"C. trachomatis","x":"mDAP","bridge":[],"cross":"43","enzspecies":["C. trachomatis"],"synth":"保留PG前体及PBP相关系统；细胞空间分布不同于完整sacculus模型","notes":["示意局部PG化学连接，不代表整细胞外围都有连续厚壁。\nAmiA已有生化研究；不能沿用“衣原体完全没有PG”的旧说法。"],"refs":["R62","R63"],"gln":false,"modified":"","unknown":false,"i18n":{"en":{"title":"Chlamydia · local division PG","synth":"PG precursor and PBP-associated pathways persist; spatial organization differs from a continuous sacculus.","notes":["Local chemical connectivity is shown, not a thick wall around the whole cell. AmiA has biochemical evidence; the older claim that Chlamydia entirely lacks PG is incorrect."]},"es":{"title":"Chlamydia · PG local de división","synth":"Se conservan rutas de precursores PG y PBP; la organización espacial difiere de un sáculo continuo.","notes":["Se muestra conectividad local, no una pared gruesa alrededor de toda la célula. AmiA tiene evidencia bioquímica; la afirmación antigua de ausencia total de PG es incorrecta."]}},"chemotype":"A1γ","chemotypeReview":{"kind":"existing_plate","plateSlug":"chlamydia","chemotype":"A1γ","dsmzCode":"A31","checked":"2026-11-07","reviewStatus":"official_nomenclature_mapping","scope":{"en":"Classification of the displayed structural subgroup, not a universal species assignment.","zh":"仅给所示结构亚型分型，不代表该物种的所有菌株或产物。","es":"Clasificación del subgrupo estructural mostrado, no de toda la especie."},"note":{"en":"A1γ labels the displayed 4→3 direct meso-DAP topology; it does not certify every native unit or glycan modification.","zh":"A1γ 标记所画 meso-DAP 直接 4→3 拓扑，不等于已核实每个原生单元或糖链修饰。","es":"A1γ identifica la topología directa meso-DAP 4→3 mostrada; no certifica cada unidad nativa ni sus modificaciones."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A31","access":"full_text","sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A31","access":"full_text","role":"official_nomenclature"}],"originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"assignmentBasis":"Mapping of the current plate's declared structure to official nomenclature; not a new species-level structural validation.","nativeStructureReview":"not_reaudited_in_this_nomenclature_task","displayedStructure":{"residue3":"mDAP","bridgeFromAcceptor":[],"crosslink":"4→3"},"diagramAction":"label_only_do_not_change_bonds","sourceIds":["REF0198","REF0200"]}}],"coverage":[["S. aureus","L-Lys–Gly₅","staph","结构与多个切点"],["S. epidermidis","Gly/Ser-Lys","staph","结构变体；AtlE另列"],["E. faecalis","L-Lys–L-Ala₂–₃","faecalis","结构与主要切点"],["E. faecium","L-Lys–D-Asx","faecium","4→3与3→3分别画"],["S. pneumoniae","直接Lys或二肽桥","pneumo","混合结构"],["S. pyogenes","L-Lys–L-Ala₂–₃","strepto","切点未定条目保留"],["S. agalactiae","Ala/Ala-Ser桥","strepto","结构变体"],["S. mutans","Ala2-3-Lys","strepto","结构变体"],["S. suis","直接Lys","lys_direct","不移植其他菌酶名"],["S. oralis","菌株依赖：直接 Lys 或 L-Ala 桥","special_cases","Uo5 为 L-Ala 桥，不统一套用直接 Lys 模型"],["Lactococcus lactis","L-Lys–D-Asx","lactis","结构与主要切点"],["Lactiplantibacillus plantarum","直接mDAP","plantarum","前体可D-Ala-D-Lac"],["B. subtilis","直接mDAP","bacillus","营养细胞与芽孢分开"],["B. cereus","直接mDAP","bacillus","结构类覆盖；酶名不可照搬"],["L. monocytogenes","直接mDAP","listeria","NamA命名歧义保留"],["C. difficile","主要3→3 mDAP","cdiff","非典型连接另有报道"],["C. perfringens","LL-DAP-Gly","lldap","经典结构证据"],["Streptomyces spp.","LL-DAP-Gly","lldap","种间变化"],["C. glutamicum","酰胺化mDAP","corynebacterium","结构/修饰独立列图"],["M. tuberculosis","mDAP，3→3/4→3","mycobacterium","糖与肽的修饰"],["M. smegmatis","mDAP，3→3/4→3","mycobacterium","类覆盖；不照搬Mtb酶目录"],["E. coli","mDAP，4→3/3→3","ecoli","主要酶与回收分开"],["Salmonella enterica","典型直接mDAP","ecoli","仅结构类；需株级酶目录"],["Shigella spp.","典型直接mDAP","ecoli","仅结构类；需株级酶目录"],["Klebsiella pneumoniae","典型直接mDAP","ecoli","仅结构类；需株级酶目录"],["Enterobacter spp.","典型直接mDAP","ecoli","仅结构类；需株级酶目录"],["Citrobacter spp.","典型直接mDAP","ecoli","仅结构类；需株级酶目录"],["Serratia marcescens","典型直接mDAP","ecoli","仅结构类；需株级酶目录"],["Proteus mirabilis","典型直接mDAP","ecoli","仅结构类；需株级酶目录"],["P. aeruginosa","直接mDAP","pseudomonas","研究酶与候选分开"],["A. baumannii","mDAP，4→3/3→3","acinetobacter","ElsL不是Ldt"],["V. cholerae","直接mDAP","vibrio","Shy酶切点"],["N. gonorrhoeae","直接mDAP","neisseria","与脑膜炎奈瑟菌差异"],["N. meningitidis","直接mDAP","neisseria","与淋病奈瑟菌差异"],["H. influenzae","典型直接mDAP","ecoli","仅结构类；需株级酶目录"],["H. pylori","直接mDAP","helical","肽干修剪"],["C. jejuni","直接mDAP","helical","肽干修剪"],["B. fragilis / B. thetaiotaomicron","mDAP型","ecoli","仅组成/化学类；不可移植整套酶"],["F. nucleatum","lanthionine型","fusobacterium","特殊第3位"],["A. muciniphila","mDAP型，常脱乙酰化","ecoli","只参照骨架；修饰/酶另核"],["B. adolescentis","Lys/Orn混合，D-Asx桥","bifido","菌株和亚群限定"],["B. bifidum / B. infantis","Orn占优，特异桥","special_cases","不以Lys图替代完整化学式"],["B. burgdorferi","Orn-Gly","borrelia","特殊骨架"],["C. trachomatis","分裂局部PG","chlamydia","无经典厚连续sacculus"],["Mycoplasma / Ureaplasma","没有经典PG","special_cases","不画虚构PG合成/水解网络"]],"references":{"R01":["Staphylococcus aureus as an emerging model to study bacterial cell division.","https://pmc.ncbi.nlm.nih.gov/articles/PMC12272431/"],"R02":["In vitro assembly of a complete, pentaglycine interpeptide bridge containing 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L,D-transpeptidases catalyze a novel type of peptidoglycan cross-links and are not required for beta-lactam resistance.","https://pmc.ncbi.nlm.nih.gov/articles/PMC10792238/"],"R41":["C. perfringens / Streptomyces LL-DAP-Gly structure, 1970.","https://orbi.uliege.be/handle/2268/85150"],"R42":["Diaminopimelic Acid Amidation in Corynebacteriales: NEW INSIGHTS INTO THE ROLE OF LtsA IN PEPTIDOGLYCAN MODIFICATION.","https://pmc.ncbi.nlm.nih.gov/articles/PMC4505564/"],"R43":["The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation.","https://pubmed.ncbi.nlm.nih.gov/18408028/"],"R44":["Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis.","https://pmc.ncbi.nlm.nih.gov/articles/PMC3468717/"],"R45":["Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host.","https://pmc.ncbi.nlm.nih.gov/articles/PMC7064781/"],"R46":["Three redundant murein endopeptidases catalyse an essential cleavage step in peptidoglycan synthesis of Escherichia coli K12.","https://pubmed.ncbi.nlm.nih.gov/23062283/"],"R47":["Role of endopeptidases in peptidoglycan synthesis mediated by alternative cross-linking enzymes in Escherichia coli.","https://pmc.ncbi.nlm.nih.gov/articles/PMC8488565/"],"R48":["A Proteolytic Complex Targets Multiple Cell Wall Hydrolases in Pseudomonas aeruginosa.","https://pmc.ncbi.nlm.nih.gov/articles/PMC6050968/"],"R49":["A New Class of Cell Wall-Recycling l,d-Carboxypeptidase Determines β-Lactam Susceptibility and Morphogenesis in Acinetobacter baumannii.","https://pmc.ncbi.nlm.nih.gov/articles/PMC8649774/"],"R50":["Peptidoglycan Recycling Promotes Outer Membrane Integrity and Carbapenem Tolerance in Acinetobacter baumannii.","https://pmc.ncbi.nlm.nih.gov/articles/PMC9239154/"],"R51":["Substrate specificity of an elongation-specific peptidoglycan endopeptidase and its implications for cell wall architecture 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anti-inflammatory peptidoglycan fragments of the gut microbiota.","https://pmc.ncbi.nlm.nih.gov/articles/PMC10829024/"],"R57":["B. bifidum var. pennsylvanicus Orn/Ser/Asn structure, 1971.","https://www.sciencedirect.com/science/article/pii/0003986171902001"],"R58":["Peptidoglycan precursor from Fusobacterium nucleatum contains lanthionine.","https://pubmed.ncbi.nlm.nih.gov/1987169/"],"R59":["Peptidoglycan composition of gramnegative obligately anaerobic rods.","https://www.jstage.jst.go.jp/article/jgam1955/27/3/27_3_199/_article/-char/en"],"R60":["Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis.","https://pmc.ncbi.nlm.nih.gov/articles/PMC6613144/"],"R61":["Bacterial and host enzymes modulate the inflammatory response produced by the peptidoglycan of the Lyme disease agent.","https://pmc.ncbi.nlm.nih.gov/articles/PMC11741416/"],"R62":["Pathogenic Chlamydia Lack a Classical Sacculus but Synthesize a Narrow, Mid-cell Peptidoglycan Ring, Regulated by MreB, for Cell Division.","https://pubmed.ncbi.nlm.nih.gov/27144308/"],"R63":["Characterization of the cell division-associated peptidoglycan amidase AmiA of Chlamydia trachomatis.","https://pmc.ncbi.nlm.nih.gov/articles/PMC13104611/"],"R64":["RodA/SEDS PG polymerase discovery, 2016.","https://www.nature.com/articles/nature19331"],"R65":["FtsW-bPBP PG polymerase activity, 2019.","https://www.nature.com/articles/s41564-018-0345-x"],"R66":["MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis","https://doi.org/10.1126/science.1254522"],"R67":["A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.","https://pmc.ncbi.nlm.nih.gov/articles/PMC2266831/"],"R68":["S. aureus LtaS mechanism, 2009.","https://pmc.ncbi.nlm.nih.gov/articles/PMC2635763/"],"R69":["Peptidoglycan Hydrolases of Escherichia coli","https://journals.asm.org/doi/10.1128/mmbr.00022-11"],"R70":["Bacterial PG 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E. coli YcbB and glycosyltransferase inventory.","https://elifesciences.org/articles/19469"],"R103":["Cleavage of Braun's lipoprotein Lpp from the bacterial peptidoglycan by a paralog of l,d-transpeptidases, LdtF.","https://pmc.ncbi.nlm.nih.gov/articles/PMC8126863/"],"R104":["Roles of low-molecular-weight penicillin-binding proteins in Bacillus subtilis spore peptidoglycan synthesis and spore properties.","https://pmc.ncbi.nlm.nih.gov/articles/PMC103540/"],"R105":["Neisseria gonorrhoeae penicillin-binding protein 3 demonstrates a pronounced preference for N(epsilon)-acylated substrates.","https://pmc.ncbi.nlm.nih.gov/articles/PMC2756183/"],"R106":["Choline-Binding Protein D (CbpD) inStreptococcus pneumoniaeIs Essential for Competence-Induced Cell Lysis","https://doi.org/10.1128/jb.187.13.4338-4345.2005"],"R107":["Bacillus subtilis CwlP of the SP-{beta} prophage has two novel peptidoglycan hydrolase domains, muramidase and cross-linkage digesting DD-endopeptidase.","https://pmc.ncbi.nlm.nih.gov/articles/PMC3009849/"],"R108":["Characterization of LytH, a differentiation-associated peptidoglycan hydrolase of Bacillus subtilis involved in endospore cortex maturation.","https://pmc.ncbi.nlm.nih.gov/articles/PMC161573/"],"R109":["Forespore Targeting of SpoVD in Bacillus subtilis Is Mediated by the N-Terminal Part of the Protein","https://doi.org/10.1128/jb.00163-18"],"R110":["The RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation-promoting factor catalytic domain","https://doi.org/10.1107/S2053230X1401317X"],"R111":["P. aeruginosa RlpA and denuded PG substrate, 2022.","https://www.nature.com/articles/s42003-022-04230-x"],"R112":["New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus.","https://pmc.ncbi.nlm.nih.gov/articles/PMC2168699/"],"R113":["Staphylococcal major autolysin (Atl) is involved in excretion of cytoplasmic proteins.","https://pmc.ncbi.nlm.nih.gov/articles/PMC2978608/"],"R114":["Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy.","https://pmc.ncbi.nlm.nih.gov/articles/PMC9503018/"],"R115":["Cell death of Streptococcus mutans induced by a quorum-sensing peptide occurs via a conserved streptococcal autolysin.","https://pmc.ncbi.nlm.nih.gov/articles/PMC3536168/"],"R116":["Litzinger et al., 2010. B. subtilis NagZ and AmiE muropeptide rescue and substrate specificity.","https://pmc.ncbi.nlm.nih.gov/articles/PMC2901692/"],"R117":["The exo-beta-N-acetylmuramidase NamZ from Bacillus subtilis, 2021.","https://pmc.ncbi.nlm.nih.gov/articles/PMC8054146/"],"R118":["Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division","https://elifesciences.org/articles/94336"],"R119":["The SH3b cell wall–binding domain of SpM23_B peptidoglycan hydrolase has antimicrobial activity","https://link.springer.com/article/10.1186/s12915-026-02773-7"],"R120":["Peptidoglycan permease AmpG1 couples lytic transglycosylase activity to muropeptide import in Acinetobacter baumannii.","https://pubmed.ncbi.nlm.nih.gov/42497993/"],"R121":["The lytic transglycosylase MltA participates in turnover of septal peptidoglycan in Escherichia coli.","https://pubmed.ncbi.nlm.nih.gov/42146403/"],"R122":["A methanogen hydrolase reveals the structure of archaeal peptidoglycan","https://www.nature.com/articles/s41586-026-11028-y"],"R123":["Biochemical characterization of Bifidobacterium bifidum peptidoglycan d,l-endopeptidase BbMep that generates NOD2 ligands.","https://pmc.ncbi.nlm.nih.gov/articles/PMC12160582/"],"R124":["A software tool and strategy for peptidoglycomics, the high-resolution analysis of bacterial peptidoglycans via LC-MS/MS","https://www.nature.com/articles/s42004-025-01490-6"],"R125":["Salmonella encodes murein lipoproteins differing in the anchoring to peptidoglycan and intermolecular association.","https://pubmed.ncbi.nlm.nih.gov/41362371/"],"R126":["The peptidoglycan and biofilm matrix of Staphylococcus epidermidis undergo structural changes when exposed to human platelets","https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211132"],"R127":["The structure of the cell wall peptidoglycan of Bacillus cereus RSVF1, a strain closely related to Bacillus anthracis.","https://pubmed.ncbi.nlm.nih.gov/15256021/"],"R128":["A Highly Active and Negatively Charged Streptococcus pyogenes Lysin with a Rare d -Alanyl- l -Alanine Endopeptidase Activity Protects Mice against Streptococcal Bacteremia","https://journals.asm.org/doi/full/10.1128/aac.00115-14"],"R129":["Role of the Group B Antigen of Streptococcus agalactiae: A Peptidoglycan-Anchored Polysaccharide Involved in Cell Wall Biogenesis","https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002756"],"R130":["Identification of a point mutation resulting in loss of cell wall anchoring activity of SrtA of Streptococcus mutans NG5.","https://pmc.ncbi.nlm.nih.gov/articles/PMC427452/"],"R131":["Significant contribution of the pgdA gene to the virulence of Streptococcus suis","https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2958.2008.06463.x"],"R132":["Molecular Relationships and Classification of Some Viridans Streptococci as Streptococcus oralis and Emended 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acnes.","https://pubmed.ncbi.nlm.nih.gov/6811573/"],"R138":["Genetic and Biochemical Characterization of the Cell Wall Hydrolase Activity of the Major Secreted Protein of Lactobacillus rhamnosus GG","https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031588"],"R139":["High-throughput Automated Muropeptide Analysis (HAMA) Reveals Peptidoglycan Composition of Gut Microbial Cell Walls","https://elifesciences.org/reviewed-preprints/88491"],"R140":["Peptidoglycan from Akkermansia muciniphila MucT: chemical structure and immunostimulatory properties of muropeptides","https://research.wur.nl/en/publications/peptidoglycan-from-akkermansia-muciniphila-mucsuptsupchemical-str/"],"R141":["Peptidoglycan from Bifidobacterium adolescentis enhances IL-10 production in regulatory B cells to alleviate gut inflammation.","https://pmc.ncbi.nlm.nih.gov/articles/PMC12795277/"],"R142":["Genomic and functional diversity of the human-derived isolates of 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subtilis CwlP of the SP-{beta} prophage has two novel peptidoglycan hydrolase domains, muramidase and cross-linkage digesting DD-endopeptidase.","https://pmc.ncbi.nlm.nih.gov/articles/PMC3009849/"],"REF0180":["Identification and characterization of novel cell wall hydrolase CwlT: a two-domain autolysin exhibiting N-acetylmuramidase and DL-endopeptidase activities.","https://pubmed.ncbi.nlm.nih.gov/18305117/"],"REF0181":["Evolution of enzymatic activities in the enolase superfamily: functional assignment of unknown proteins in Bacillus subtilis and Escherichia coli as L-Ala-D/L-Glu epimerases.","https://pubs.acs.org/doi/10.1021/bi011640x"],"REF0182":["Characterization of new L,D-endopeptidase gene product CwlK (previous YcdD) that hydrolyzes peptidoglycan in Bacillus subtilis","https://pubmed.ncbi.nlm.nih.gov/17588176/"],"REF0108":["Characterization of LytH, a differentiation-associated peptidoglycan hydrolase of Bacillus subtilis involved in endospore cortex 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Crystal structure of the muramidase from Streptomyces coelicolor at 1.65 A resolution","https://pubmed.ncbi.nlm.nih.gov/11427528/"],"REF0188":["The bacterial septal ring protein RlpA is a lytic transglycosylase that contributes to rod shape and daughter cell separation in Pseudomonas aeruginosa","https://pmc.ncbi.nlm.nih.gov/articles/PMC4086221/"],"REF0157":["Peptidoglycan structure analysis of Lactococcus lactis reveals the presence of an L,D-carboxypeptidase involved in peptidoglycan maturation.","https://doi.org/10.1128/JB.00285-06"],"REF0017":["Aslfm, the D-aspartate ligase responsible for the addition of D-aspartic acid onto the peptidoglycan precursor of Enterococcus faecium.","https://pubmed.ncbi.nlm.nih.gov/16510449/"],"REF0189":["The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis.","https://doi.org/10.1111/j.1574-6976.2008.00105.x"],"REF0190":["Cloning and characterization of PBP 1C, a third member of the multimodular class A penicillin-binding proteins of Escherichia coli.","https://pubmed.ncbi.nlm.nih.gov/10542235/"],"REF0191":["The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN.","https://pmc.ncbi.nlm.nih.gov/articles/PMC2258671/"],"REF0192":["N Glycolylation of the nucleotide precursors of peptidoglycan biosynthesis of Mycobacterium spp. is altered by drug treatment.","https://pubmed.ncbi.nlm.nih.gov/15774877/"],"REF0193":["Identification of the namH gene, encoding the hydroxylase responsible for the N-glycolylation of the mycobacterial peptidoglycan.","https://pubmed.ncbi.nlm.nih.gov/15522883/"],"REF0194":["Structural basis for autoinhibition and activation of Auto, a virulence-associated peptidoglycan hydrolase of Listeria monocytogenes.","https://doi.org/10.1111/j.1365-2958.2009.06619.x"],"REF0195":["Molecular characterization of an autolytic amidase of Listeria monocytogenes EGD.","https://pubmed.ncbi.nlm.nih.gov/9611810/"],"REF0196":["Identification and characterization of a peptidoglycan hydrolase, MurA, of Listeria monocytogenes, a muramidase needed for cell separation.","https://pmc.ncbi.nlm.nih.gov/articles/PMC262698/"],"REF0197":["Multiple Low-Reactivity Class B Penicillin-Binding Proteins Are Required for Cephalosporin Resistance in Enterococci.","https://doi.org/10.1128/AAC.02273-19"],"REF0198":["Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans"],"REF0199":["DSMZ culture record DSM20231","https://www.dsmz.de/collection/catalogue/details/culture/DSM-20231"],"REF0200":["Peptidoglycan types of bacterial cell walls and their taxonomic implications","https://pubmed.ncbi.nlm.nih.gov/4568761/"],"REF0201":["DSMZ culture record DSM20175","https://www.dsmz.de/collection/catalogue/details/culture/DSM-20175"],"REF0202":["Composition of peptidoglycans in Bacteroidaceae: determination and distribution of lanthionine","https://pubmed.ncbi.nlm.nih.gov/7076290/"],"REF0203":["DSMZ culture record DSM20482","https://www.dsmz.de/collection/catalogue/details/culture/dsm-20482"],"REF0060":["Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis.","https://pmc.ncbi.nlm.nih.gov/articles/PMC6613144/"],"REF0204":["The use of photolysis of dinitrophenyl-peptides in structural studies on the cell-wall mucopeptide of Corynebacterium poinsettiae","https://portlandpress.com/biochemj/article-pdf/102/2/29C/758212/bj1020029c.pdf"],"REF0205":["DSMZ culture record DSM20149","https://www.dsmz.de/collection/catalogue/details/culture/dsm-20149"],"REF0206":["DSMZ culture record DSM1790","https://www.dsmz.de/collection/catalogue/details/culture/DSM-1790"],"REF0207":["Micrococcus lysodeikticus: a new type of cross-linkage of the murein","https://pubmed.ncbi.nlm.nih.gov/6064598/"],"REF0208":["Structure of the cell walls of Micrococcus lysodeikticus. 3. 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mDAP","Vegetative cells and spores distinguished"],"es":["mDAP directo","Se distinguen células vegetativas y esporas"]},"B. cereus":{"en":["Direct mDAP","Chemotype coverage; enzyme names need species-specific evidence"],"es":["mDAP directo","Cobertura de quimiotipo; las enzimas requieren evidencia de la especie"]},"L. monocytogenes":{"en":["Direct mDAP","NamA naming ambiguity retained"],"es":["mDAP directo","Se conserva la ambigüedad del nombre NamA"]},"C. difficile":{"en":["Predominantly 3→3 mDAP","Additional atypical links have been reported"],"es":["mDAP, principalmente 3→3","También se han descrito enlaces atípicos"]},"C. perfringens":{"en":["LL-DAP-Gly","Classical structural evidence"],"es":["LL-DAP-Gly","Evidencia estructural clásica"]},"Streptomyces spp.":{"en":["LL-DAP-Gly","Variation between species"],"es":["LL-DAP-Gly","Variación entre especies"]},"C. glutamicum":{"en":["Amidated mDAP","Structure and modifications shown separately"],"es":["mDAP amidado","Estructura y modificaciones representadas por separado"]},"M. tuberculosis":{"en":["mDAP, 3→3 / 4→3","Glycan and peptide modifications"],"es":["mDAP, 3→3 / 4→3","Modificaciones del glicano y del péptido"]},"M. smegmatis":{"en":["mDAP, 3→3 / 4→3","Chemotype coverage; the Mtb enzyme catalog is not transferred"],"es":["mDAP, 3→3 / 4→3","Cobertura de quimiotipo; no se transfiere el catálogo enzimático de Mtb"]},"E. coli":{"en":["mDAP, 4→3 / 3→3","Major wall enzymes and recycling distinguished"],"es":["mDAP, 4→3 / 3→3","Se distinguen enzimas de pared y reciclaje"]},"Salmonella enterica":{"en":["Typical direct mDAP","Chemotype only; a strain-specific enzyme catalog is needed"],"es":["mDAP directo típico","Solo quimiotipo; se requiere un catálogo enzimático de la cepa"]},"Shigella spp.":{"en":["Typical direct mDAP","Chemotype only; a strain-specific enzyme catalog is needed"],"es":["mDAP directo típico","Solo quimiotipo; se requiere un catálogo enzimático de la cepa"]},"Klebsiella pneumoniae":{"en":["Typical direct mDAP","Chemotype only; a strain-specific enzyme catalog is needed"],"es":["mDAP directo típico","Solo quimiotipo; se requiere un catálogo enzimático de la cepa"]},"Enterobacter spp.":{"en":["Typical direct mDAP","Chemotype only; a strain-specific enzyme catalog is needed"],"es":["mDAP directo típico","Solo quimiotipo; se requiere un catálogo enzimático de la cepa"]},"Citrobacter spp.":{"en":["Typical direct mDAP","Chemotype only; a strain-specific enzyme catalog is needed"],"es":["mDAP directo típico","Solo quimiotipo; se requiere un catálogo enzimático de la cepa"]},"Serratia marcescens":{"en":["Typical direct mDAP","Chemotype only; a strain-specific enzyme catalog is needed"],"es":["mDAP directo típico","Solo quimiotipo; se requiere un catálogo enzimático de la cepa"]},"Proteus mirabilis":{"en":["Typical direct mDAP","Chemotype only; a strain-specific enzyme catalog is needed"],"es":["mDAP directo típico","Solo quimiotipo; se requiere un catálogo enzimático de la cepa"]},"P. aeruginosa":{"en":["Direct mDAP","Characterized enzymes and candidates distinguished"],"es":["mDAP directo","Se distinguen enzimas caracterizadas y candidatas"]},"A. baumannii":{"en":["mDAP, 4→3 / 3→3","ElsL is not an Ldt"],"es":["mDAP, 4→3 / 3→3","ElsL no es una Ldt"]},"V. cholerae":{"en":["Direct mDAP","Shy enzyme cleavage sites"],"es":["mDAP directo","Sitios de corte de enzimas Shy"]},"N. gonorrhoeae":{"en":["Direct mDAP","Differences from N. meningitidis retained"],"es":["mDAP directo","Se conservan diferencias con N. meningitidis"]},"N. meningitidis":{"en":["Direct mDAP","Differences from N. gonorrhoeae retained"],"es":["mDAP directo","Se conservan diferencias con N. gonorrhoeae"]},"H. influenzae":{"en":["Typical direct mDAP","Chemotype only; a strain-specific enzyme catalog is needed"],"es":["mDAP directo típico","Solo quimiotipo; se requiere un catálogo enzimático de la cepa"]},"H. pylori":{"en":["Direct mDAP","Peptide-stem trimming"],"es":["mDAP directo","Recorte del tallo peptídico"]},"C. jejuni":{"en":["Direct mDAP","Peptide-stem trimming"],"es":["mDAP directo","Recorte del tallo peptídico"]},"B. fragilis / B. thetaiotaomicron":{"en":["mDAP type","Composition/chemotype only; do not transfer the full enzyme set"],"es":["Tipo mDAP","Solo composición/quimiotipo; no transferir todo el conjunto enzimático"]},"F. nucleatum":{"en":["Lanthionine type","Distinctive residue at position 3"],"es":["Tipo lantionina","Residuo particular en la posición 3"]},"A. muciniphila":{"en":["mDAP type; often deacetylated","Backbone reference only; verify modifications and enzymes separately"],"es":["Tipo mDAP; a menudo desacetilado","Solo referencia del esqueleto; verificar aparte modificaciones y enzimas"]},"B. adolescentis":{"en":["Mixed Lys/Orn; D-Asx bridge","Strain and subpopulation restrictions apply"],"es":["Mezcla Lys/Orn; puente D-Asx","Sujeto a diferencias entre cepas y subpoblaciones"]},"B. bifidum / B. infantis":{"en":["Orn-rich; distinctive bridges","A Lys diagram cannot replace the complete chemical structure"],"es":["Predominio de Orn; puentes específicos","Un esquema de Lys no sustituye la estructura química completa"]},"B. burgdorferi":{"en":["Orn-Gly","Distinctive backbone"],"es":["Orn-Gly","Esqueleto particular"]},"C. trachomatis":{"en":["PG localized at division","No classical thick, continuous sacculus"],"es":["PG localizado en la división","Sin sáculo grueso y continuo clásico"]},"Mycoplasma / Ureaplasma":{"en":["No classical PG","No invented PG synthesis/hydrolysis network"],"es":["Sin PG clásico","No se inventa una red de síntesis/hidrólisis de PG"]}},"catalogVersion":"2.2","audits":[{"species":"S. aureus","label":{"zh":"原生 PBP 名称组","en":"Native PBP set","es":"Conjunto de PBP nativas"},"expected":4,"ids":["E140","E141","E142","E147"],"refs":["R78","R92","R101"]},{"species":"E. faecalis","label":{"zh":"高分子量 PBP 名称组","en":"High-mass PBP set","es":"PBP de alta masa"},"expected":6,"ids":["E123","E124","E125","E126","E127","E128"],"refs":["R80"]},{"species":"E. faecium","label":{"zh":"高分子量 PBP 名称组","en":"High-mass PBP set","es":"PBP de alta masa"},"expected":6,"ids":["E129","E130","E131","E132","E133","E134"],"refs":["R81"]},{"species":"B. subtilis","label":{"zh":"16 个 PBP 的文献目录","en":"16-PBP literature inventory","es":"Inventario bibliográfico de 16 PBP"},"expected":16,"ids":["E166","E167","E168","E169","E170","E171","E172","E173","E174","E175","E176","E051","E177","E178","E195","E196"],"refs":["R79"]},{"species":"P. aeruginosa","label":{"zh":"PAO1 的 11 个 LT","en":"Eleven PAO1 LTs","es":"Once LT de PAO1"},"expected":11,"ids":["E246","E247","E248","E249","E250","E251","E252","E253","E254","E255","E256"],"refs":["R84"]},{"species":"P. aeruginosa","label":{"zh":"8 个 PBP 的文献目录","en":"Eight-PBP literature inventory","es":"Inventario bibliográfico de ocho PBP"},"expected":8,"ids":["E238","E239","E240","E241","E242","E243","E244","E245"],"refs":["R93"]},{"species":"S. pneumoniae","label":{"zh":"6 个 PBP 名称组","en":"Six-PBP set","es":"Conjunto de seis PBP"},"expected":6,"ids":["E227","E228","E229","E230","E231","E232"],"refs":["R80","R87"]},{"species":"L. monocytogenes","label":{"zh":"10 个 PBP/PBP-like 条目","en":"Ten PBP/PBP-like records","es":"Diez registros PBP/PBP-like"},"expected":10,"ids":["E259","E260","E261","E262","E263","E266","E267","E264","E265","E268"],"refs":["R99"]},{"species":"L. monocytogenes","label":{"zh":"5 个 SEDS 名称组","en":"Five-SEDS set","es":"Conjunto de cinco SEDS"},"expected":5,"ids":["E269","E270","E271","E272","E273"],"refs":["R94"]},{"species":"A. baumannii","label":{"zh":"3 个 DD 肽酶名称组","en":"Three DD-peptidases","es":"Tres DD-peptidasas"},"expected":3,"ids":["E274","E275","E095"],"refs":["R95"]}],"chemotypeExamples":[{"kind":"static_example","plateSlug":"curtobacterium_poinsettiae_static","chemotype":"B2β","dsmzCode":"B5","checked":"2026-11-07","reviewStatus":"official_type_and_primary_author_proposed_structure","scope":{"en":"Historical C. poinsettiae N.C.P.P. 177 structural model; DSM 20149 separately confirms the modern taxonomic name and B5 type.","zh":"历史 C. poinsettiae N.C.P.P. 177 的结构模型；DSM 20149 另行支持现名及 B5 分型，二者不合并为同一菌株。","es":"Modelo estructural histórico de C. poinsettiae N.C.P.P. 177; DSM 20149 confirma por separado el nombre actual y B5, sin equiparar las cepas."},"note":{"en":"The author proposed a D-Orn bridge joining stem positions 2 and 4. Preserve the specified Orn amino groups; this is not a residue-3 bridge.","zh":"作者提出 D-Orn 桥连接主肽第 2、4 位。须保留 Orn 两个氨基的具体连接，不画成第 3 位出桥。","es":"El autor propuso un puente D-Orn entre las posiciones 2 y 4 del tallo. Deben conservarse los grupos amino indicados; no es un puente desde la posición 3."},"sourceurl":"https://portlandpress.com/biochemj/article-pdf/102/2/29C/758212/bj1020029c.pdf","doi":"10.1042/bj1020029c","locator":"Perkins 1967, p.31c, Table 1 peptides E–H and Scheme 1; discussion directly below Scheme 1","access":"full_text","originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type B, row B5; endnote c","access":"full_text","role":"official_nomenclature"},{"id":"PERKINS1967","title":"The use of photolysis of dinitrophenyl-peptides in structural studies on the cell-wall mucopeptide of Corynebacterium poinsettiae","url":"https://portlandpress.com/biochemj/article-pdf/102/2/29C/758212/bj1020029c.pdf","doi":"10.1042/bj1020029c","year":1967,"locator":"pp.30c–31c; Table 1 peptides E–H; Scheme 1 and following paragraph","access":"full_text","accessNote":"Full article text and table/scheme transcription accessible; original scheme image not visually verified.","role":"native_structure_author_proposal"},{"id":"DSM20149","url":"https://www.dsmz.de/collection/catalogue/details/culture/dsm-20149","locator":"Name, strain history CP 2, pathovar poinsettiae, Murein B5","access":"full_text","role":"taxonomy_and_official_type"}],"taxonomy":{"historicalName":"Corynebacterium poinsettiae","currentCatalogueName":"Curtobacterium flaccumfaciens","pathovar":"Curtobacterium flaccumfaciens pv. poinsettiae","historicalStudyStrain":"N.C.P.P. 177","officialExample":{"strain":"DSM 20149 / CP 2","sameAsHistoricalStudyStrain":null}},"diagramEvidence":"author_proposed_primary_scheme","diagram":{"type":"native_peptide_crosslink_schematic","drawFullNativeNetwork":false,"allowStaticSchematic":true,"animate":false,"crosslinkPositions":[2,4],"stem":["Gly","D-Glu","L-Hse","D-Ala"],"bridgeFromStemPosition":2,"bridge":["D-Orn"],"knownNodes":[{"id":"A1","unit":"A","position":1,"label":"Gly"},{"id":"A2","unit":"A","position":2,"label":"D-Glu"},{"id":"A3","unit":"A","position":3,"label":"L-Hse"},{"id":"A4","unit":"A","position":4,"label":"D-Ala"},{"id":"B1","unit":"B","position":1,"label":"Gly"},{"id":"B2","unit":"B","position":2,"label":"D-Glu"},{"id":"B3","unit":"B","position":3,"label":"L-Hse"},{"id":"B4","unit":"B","position":4,"label":"D-Ala"},{"id":"bridge1","unit":null,"position":null,"label":"D-Orn","freeGroup":"alpha-carboxyl"}],"explicitEdges":[{"from":"A1","fromGroup":"carboxyl","to":"A2","toGroup":"alpha-amino","kind":"stem"},{"from":"A2","fromGroup":"gamma-carboxyl","to":"A3","toGroup":"alpha-amino","kind":"stem"},{"from":"A3","fromGroup":"alpha-carboxyl","to":"A4","toGroup":"alpha-amino","kind":"stem"},{"from":"B1","fromGroup":"carboxyl","to":"B2","toGroup":"alpha-amino","kind":"stem"},{"from":"B2","fromGroup":"gamma-carboxyl","to":"B3","toGroup":"alpha-amino","kind":"stem"},{"from":"B3","fromGroup":"alpha-carboxyl","to":"B4","toGroup":"alpha-amino","kind":"stem"},{"from":"A2","fromGroup":"alpha-carboxyl","to":"bridge1","toGroup":"delta-amino","kind":"interstem_bridge","sourceId":"PERKINS1967"},{"from":"B4","fromGroup":"alpha-carboxyl","to":"bridge1","toGroup":"alpha-amino","kind":"interstem_bridge","sourceId":"PERKINS1967"}],"limits":"Residue stereochemical labels follow the official B5 classification; attachment groups follow Perkins's author-proposed scheme. Show only this peptide motif. No glycan modifications, enzyme reactions, intact-network proportions, or strain equivalence are assigned."},"sourceIds":["REF0198","REF0204","REF0205","REF0200"]},{"kind":"static_example","plateSlug":"micrococcus_luteus_a2_static","chemotype":"A2","dsmzCode":"A11.pep","requestedLabel":"A2α","checked":"2026-11-07","reviewStatus":"official_nomenclature_verified_native_diagram_pending","scope":{"en":"DSM 1790 is an official A11.pep example. Historical M. lysodeikticus papers are listed separately; strain equivalence and full native connectivity remain unverified here.","zh":"DSM 1790 为官方 A11.pep 实例；历史 M. lysodeikticus 原文另列，尚未在此核实菌株对应及完整原生连接。","es":"DSM 1790 es un ejemplo oficial de A11.pep. Los artículos históricos de M. lysodeikticus se registran por separado; no se verificaron aquí la equivalencia de cepas ni toda la conectividad nativa."},"note":{"en":"Use A2 (A11.pep) for the official label: a peptide subunit serves as the bridge. The requested A2α label was not confirmed in the accessible official table; do not invent its exact network.","zh":"官方标签采用 A2（A11.pep），由肽亚基充当桥。可访问官方表未确认所提 A2α 写法；不补造其完整连接。","es":"Usar A2 (A11.pep) como etiqueta oficial: una subunidad peptídica forma el puente. La tabla oficial accesible no confirmó A2α; no inventar su red exacta."},"sourceurl":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"locator":"Type A, row A11.pep; DSM 1790 Murein summary","access":"full_text","originalClassification":{"title":"Peptidoglycan types of bacterial cell walls and their taxonomic implications","year":1972,"doi":"10.1128/br.36.4.407-477.1972","url":"https://pubmed.ncbi.nlm.nih.gov/4568761/","access":"metadata_only","status":"pending_original_1972_text","locator":"Bibliographic record verified; original classification text and figures were not accessible during this audit."},"sources":[{"id":"DSMZ-PG","title":"Nomenclature of Peptidoglycan Structures of Cross-Linkage Types A and B","url":"https://www.dsmz.de/collection/catalogue/microorganisms/special-groups-of-organisms/peptidoglycans","doi":null,"year":null,"locator":"Type A, row A11.pep","access":"full_text","role":"official_nomenclature"},{"id":"DSM1790","url":"https://www.dsmz.de/collection/catalogue/details/culture/DSM-1790","locator":"Micrococcus luteus; strain history 130.21; Murein A11.pep","access":"full_text","role":"official_strain_example"},{"id":"SCHLEIFER1967MICRO","title":"Micrococcus lysodeikticus: a new type of cross-linkage of the murein","url":"https://pubmed.ncbi.nlm.nih.gov/6064598/","doi":"10.1016/0006-291X(67)90074-5","year":1967,"locator":"Bibliographic record only; no abstract or original structure figure accessed","access":"metadata_only","status":"pending","role":"original_structure_source_not_verified"},{"id":"GHUYSEN1968","title":"Structure of the cell walls of Micrococcus lysodeikticus. 3. Isolation of a new peptide dimer, N-alpha-[L-alanyl-gamma-(alpha-D-glutamylglycine)]-L-lysyl-D-alanyl-N-alpha-[L-alanyl-gamma-(alpha-D-glutamylglycine)]-L-lysyl-D-alanine","url":"https://pubmed.ncbi.nlm.nih.gov/5677833/","doi":"10.1021/bi00844a030","year":1968,"locator":"Article title only; original body and chemical figure unavailable in this audit","access":"metadata_only","status":"pending","role":"analytical_fragment_title_not_native_network_proof"}],"diagramEvidence":"class_only_native_connectivity_pending","diagram":{"type":"class_inventory_only","drawFullNativeNetwork":false,"allowStaticSchematic":true,"animate":false,"knownNodes":[{"id":"stem_anchor","label":"L-Lys","role":"stem_residue_3"},{"id":"bridge_block","label":"Peptide subunit","role":"bridge_component","residues":null}],"explicitEdges":[],"pendingEdges":["Exact bridge-subunit orientation and its two native attachment groups must be checked in the original structure source before atom-level connections are drawn."],"limits":"Display a labeled component inventory only. Do not interpret the complex 1968 peptide-dimer title as a verified full-wall connectivity diagram; no 4→1 or Lys attachment edge is inferred from that title."},"sourceIds":["REF0198","REF0206","REF0207","REF0208","REF0200"]}]}