Peptidoglycan Atlas

Staphylococcus aureus

S. aureus

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Staphylococcus aureus

FemX/FmhB, FemA and FemB assemble Gly5; PBP2, FtsW–PBP1 and RodA–PBP3 polymerize/crosslink PG.

Atlas notes

  • Gly1 is nearest acceptor Lys. LytM acts at BR and 43; LytH at A, preferentially on uncrosslinked PG. IsaA/SceD remain putative LTs. SpdC/ActH are partners, not cleavage sites.

金黄色葡萄球菌

FemX/FmhB + FemA + FemB: Gly桥；PBP2、FtsW-PBP1、RodA-PBP3：聚合/交联

图谱说明

  • Gly1定义为最靠近受体Lys的Gly；桥的游离N端靠近供体。 LytM：同时标BR和43；LytH：标A，且偏好未交联PG。 IsaA/SceD的LT判定保留为候选；SpdC/ActH不画切割箭头。

Staphylococcus aureus

FemX/FmhB, FemA y FemB ensamblan Gly5; PBP2, FtsW–PBP1 y RodA–PBP3 polimerizan/entrecruzan PG.

Notas del atlas

  • Gly1 está junto a Lys aceptora. LytM actúa en BR y 43; LytH en A, preferentemente en PG sin entrecruzar. IsaA/SceD siguen siendo LT propuestas. SpdC/ActH son proteínas asociadas.

Linked enzyme entries / 关联酶条目 / Entradas enzimáticas vinculadas

Cited sources / 引用来源 / Fuentes citadas

  1. R02 In vitro assembly of a complete, pentaglycine interpeptide bridge containing cell wall precursor (lipid II-Gly5) of Staphylococcus aureus.
  2. R03 Perturbation of Cell Wall Synthesis Suppresses Autolysis in Staphylococcus aureus : Evidence for Coregulation of Cell Wall Synthetic and Hydrolytic Enzymes
  3. R04 SagB Glucosaminidase Is a Determinant of Staphylococcus aureus Glycan Chain Length, Antibiotic Susceptibility, and Protein Secretion.
  4. R05 LytN, a murein hydrolase in the cross-wall compartment of Staphylococcus aureus, is involved in proper bacterial growth and envelope assembly.
  5. R06 EssH Peptidoglycan Hydrolase Enables Staphylococcus aureus Type VII Secretion across the Bacterial Cell Wall Envelope.
  6. R07 Identification and structural characterization of LytU, a unique peptidoglycan endopeptidase from the lysostaphin family.
  7. R08 Reassessing the substrate specificities of the major Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM.
  8. R09 LytH-ActH removes stems from uncrosslinked PG, 2020.
  9. R10 Characterization of IsaA and SceD, two putative lytic transglycosylases of Staphylococcus aureus.